1-Chloro-3-fluoro-2-(trifluoromethoxy)benzene CAS 1404193-77-6
| CAS No. | 1404193-77-6 |
| Molecular Formula | C7H3ClF4O |
| Molecular Weight | 214.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Chloro-3-fluoro-2-(trifluoromethoxy)benzene.
1-Chloro-3-fluoro-2-(trifluoromethoxy)benzene (CAS 1404193-77-6), molecular formula C7H3ClF4O and molecular weight 214.54 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 1-Chloro-3-fluoro-2-(trifluoromethoxy)benzene (C7H3ClF4O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 214.54 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3ClF4O |
| Molecular Weight | 214.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-Chloro-4-fluoro-2-(trifluoromethoxy)benzene (CAS 114021-45-3)
- 2-Chloro-6-fluoro-4-(trifluoromethyl)phenol (CAS 116640-09-6)
- 1-[Chloro(difluoro)methoxy]-2,4-difluoro-benzene (CAS 123572-68-9)
- 2-Chloro-6-fluoro-3-(trifluoromethyl)phenol (CAS 1254781-50-4)
- 1-Chloro-3-(difluoromethoxy)-2,4-difluorobenzene (CAS 1261769-13-4)
- 1-Chloro-5-(difluoromethoxy)-2,4-difluorobenzene (CAS 1261808-36-9)
- 2-Chloro-5-(difluoromethoxy)-1,3-difluorobenzene (CAS 1261846-38-1)
- 2-Chloro-3-(difluoromethoxy)-1,4-difluoro-benzene (CAS 1261869-12-8)
Recommended Standards
- 1-[Chloro(difluoro)methoxy]-2,3-difluoro-benzene (CAS 1404193-57-2)
- 2-Chloro-4-fluoro-1-(trifluoromethoxy)benzene (CAS 1404194-16-6)
- 2-Chloro-1-fluoro-4-(trifluoromethoxy)benzene (CAS 128540-52-3)
- 1-Chloro-2-fluoro-4-(trifluoromethoxy)benzene (CAS 1404194-19-9)
- 3-Chloro-4-(2-chloro-5-methylphenoxy)aniline (CAS 946662-58-4)
- 4,4'-(Furan-2,5-diyl)bis(N-ethylbenzimidamide) (CAS 199919-01-2)
- 2,2,4-Trimethyl-2,3-dihydro-1-benzofuran-7-amine (CAS 756431-31-9)
- 1142210-12-5 4-({[5-(2-Fluorobenzyl)-1,3,4-thiadiazol-2-yl]-carbonyl}amino)benzoic acid 9407AC C17H12FN3O3S (CAS 1142210-12-5)
- 7-Methoxy-5-nitro-3-(trifluoromethyl)benzofuran (CAS 1400764-49-9)
- 6-Nitro-1H-pyrrolo[3,2-b]pyridine (CAS 1190318-66-1)
- 2-[2-(Benzyloxy)-4-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2246670-77-7)
- 2,2,2-Trifluoro-1-(2-(trifluoromethoxy)phenyl)ethanamine (CAS 1270440-28-2)
- 2,6-Dimethyl-1H-purine (CAS 5943-89-5)
- Semaglutide impurity 88 (CAS CATO-C4X-222688)
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