Levofloxacin Impurity 83 CAS 1268719-66-9
| CAS No. | 1268719-66-9 |
| Molecular Formula | C19H22FN3O4 |
| Molecular Weight | 375.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Levofloxacin Impurity 83 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Levofloxacin Impurity 83 (CAS 1268719-66-9) is a certified pharmaceutical impurity reference standard with the molecular formula C19H22FN3O4 and a molecular weight of 375.39 g/mol.
Structurally, Levofloxacin Impurity 83 (C19H22FN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 375.39 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22FN3O4 |
| Molecular Weight | 375.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Levofloxacin Standards
- Levofloxacin Impurity 34 (CAS 108224-82-4)
- Levofloxacin Impurity 40 (CAS 106939-30-4)
- Levofloxacin Methyl Ester (CAS 862690-19-5)
- Levofloxacin impurity 78 (CAS 107359-24-0)
- Levofloxacin Impurity 52 (CAS 1152314-62-9)
- Levofloxacin Impurity 88 (CAS CATO-C4X-137188)
- Levofloxacin EP Impurity C(Levofloxacin N-Oxide) (CAS 117678-38-3)
- (R)-Levofloxacin N-Oxide (CAS 117678-37-2)
Recommended Standards
- Gatifloxacin (CAS 112811-59-3)
- 2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)sulfonyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (CAS 1008266-08-7)
- N-Acetyl O-Benzyl Lamivudine (CAS 1091585-30-6)
- Retigabine impurity 11 (CAS CATO-C4X-13151)
- Vitamin K1 Impurity 39 (CAS CATO-C4X-220739)
- Benidipine Impurity 11 (CAS 1185304-22-6)
- Ornidazole Impurity 65 (CAS CATO-C4X-133165)
- (R)-1-(Diphenylphosphanyl)-3-phenylpropan-2-amine (CAS 1103534-03-7)
- 6-cyclobutylmorpholin-3-one (CAS 1857078-46-6)
- 2-Cyclopropoxy-1-iodo-3-nitrobenzene (CAS 1243379-96-5)
- Acotiamide Impurity 28 (CAS 185104-11-4)
- 2-Phenyloxazole-5-carboxylic acid (CAS 106833-79-8)
- Ethyl 6-(2-chloro-4-fluorophenyl)-6-oxohexanoate (CAS 951886-25-2)
- Insulin Degludec Impurity 28 (CAS CATO-C4X-215728)
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