Sorafenib EP Impurity F CAS 1285533-84-7
| CAS No. | 1285533-84-7 |
| Molecular Formula | C21H17F3N4O3 |
| Molecular Weight | 430.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sorafenib EP Impurity F.
Sorafenib EP Impurity F (CAS 1285533-84-7) is a certified pharmaceutical impurity reference standard with the molecular formula C21H17F3N4O3 and a molecular weight of 430.38 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Sorafenib EP Impurity F is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 430.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sorafenib EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H17F3N4O3 |
| Molecular Weight | 430.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sorafenib Standards
- Sorafenib Impurity 38 (CAS 862875-16-9)
- Sorafenib Impurity 18 (CAS 284461-74-1)
- Sorafenib Impurity 16 (CAS 1012058-78-4)
- Sorafenib (Base) (CAS 284461-73-0)
- Sorafenib Impurity 40 (CAS 1290546-48-3)
- Sorafenib Impurity 42 (CAS CATO-C4X-112442)
- Sorafenib EP Impurity H (CAS 1431697-81-2)
- Sorafenib related compound 26 (CAS 573673-43-5)
Recommended Standards
- Methyl 4-(4-((2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)methyl)benzamido)benzoate (CAS 339025-42-2)
- 5-((2,4-Dinitrophenyl)amino)-2-(phenylamino)benzenesulfonic acid (CAS 15347-52-1)
- 2-Phenoxy-N'-{2-[3-(trifluoromethyl)phenoxy]ethanimidoyl}pyridine-3-carbohydrazide (CAS 337928-98-0)
- Fostriecin (CAS 87810-56-8)
- Olprinone Impurity N1 (CAS 106730-70-5)
- Upadacitinib Impurity 140 (CAS CATO-C4X-2405140)
- LCZ-696 Impurity 23 (CAS CATO-C4X-169623)
- 1,4-Dioxo-1,4-bis(tridecyloxy)butane-2-sulfonic acid (CAS 18271-58-4)
- 2-(4-Chlorophenyl)-1-(1,4-diazepan-1-yl)ethan-1-one (CAS 815651-30-0)
- Methyl6-bromoimidazo[1,2-a]pyridine-5-carboxylate (CAS 2091427-06-2)
- (2R,6R)-2,6-Diethylpiperazine (CAS 682740-57-4)
- 1-Methyl-3-phenylpiperazine-d3 (CAS 1189934-96-0)
- Ethyl 2-Bromo-5-nitrobenzoate (CAS 208176-31-2)
- Insulin Degludec Impurity 10 (CAS CATO-C4X-215710)
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