Moxifloxacin impurity 177 CAS 1293488-61-5
| CAS No. | 1293488-61-5 |
| Molecular Formula | C20H22FN3O4 |
| Molecular Weight | 387.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Moxifloxacin impurity 177 (C20H22FN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Moxifloxacin impurity 177 (CAS 1293488-61-5, C20H22FN3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H22FN3O4 |
| Molecular Weight | 387.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Moxifloxacin Standards
- Moxifloxacin impurity 178 (CAS 934841-13-1)
- Moxifloxacin EP Impurity E (CAS 721970-36-1)
- Moxifloxacin EP Impurity A (CAS 151213-15-9)
- Moxifloxacin Impurity 20 (CAS 959347-97-8)
- Moxifloxacin Impurity 56 (CAS CATO-C4X-1074156)
- Moxifloxacin impurity 167 (CAS CATO-C4X-1074167)
- Moxifloxacin Impurity 57 (CAS CATO-C4X-1074157)
- Moxifloxacin Impurity 47 (CAS 2315304-27-7)
Recommended Standards
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- (4-(Morpholinosulfonyl)-2-nitrophenyl)valine (CAS 1009549-98-7)
- Lornoxicam Impurity 47 (CAS 906522-87-0)
- Salbutamol EP Impurity D HCl(R-Isomer) (CAS CATO-C4X-1176199)
- Phenoxymethylpenicillin EP Impurity E (CAS 1049-84-9)
- 4-(1H-indol-2-yl)benzoic acid (CAS 58995-75-8)
- 1-{[4-(4-fluorophenyl)-1,3-thiazol-2-yl]methyl}piperazine dihydrochloride (CAS 1177277-61-0)
- (S)-1-(4-(Difluoromethoxy)phenyl)ethan-1-amine hydrochloride (CAS 2045362-22-7)
- Ethyl 2-(4-(tosyloxy)butoxy)acetate (CAS 149029-47-0)
- [2-(1H-1,2,4-Triazol-1-yl)ethyl]amine dihydrobromide (CAS 1448053-01-7)
- [4-(difluoromethyl)phenyl]methanesulfonyl chloride (CAS 1211518-37-4)
- Semaglutide impurity 235 (CAS CATO-C4X-2226235)
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