Hydrochlorothiazide Impurity N17 CAS 1954-94-5
| CAS No. | 1954-94-5 |
| Molecular Formula | C6H7ClN2O2 |
| Molecular Weight | 206.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Hydrochlorothiazide Impurity N17 (CAS 1954-94-5, C6H7ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Hydrochlorothiazide Impurity N17 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 206.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Hydrochlorothiazide Impurity N17 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H7ClN2O2 |
| Molecular Weight | 206.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide Impurity N8 (CAS 4140-83-4)
- Hydrochlorothiazide Impurity 1 (CAS 133-74-4)
- Hydrochlorothiazide Impurity 40 (CAS CATO-C4X-117740)
- Hydrochlorothiazide Impurity 41 (CAS CATO-C4X-117741)
- Hydrochlorothiazide Impurity (CAS 360-81-6)
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- Hydrochlorothiazide Impurity 36 (CAS CATO-C4X-117736)
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