Hydrochlorothiazide Impurity CAS 360-81-6
| CAS No. | 360-81-6 |
| Molecular Formula | C8H8N2O2S |
| Molecular Weight | 196.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Hydrochlorothiazide Impurity under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Hydrochlorothiazide Impurity (CAS 360-81-6) is a certified pharmaceutical impurity reference standard with the molecular formula C8H8N2O2S and a molecular weight of 196.23 g/mol.
The molecular framework of Hydrochlorothiazide Impurity (C8H8N2O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H8N2O2S |
| Molecular Weight | 196.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide Impurity N17 (CAS 1954-94-5)
- Hydrochlorothiazide Impurity N8 (CAS 4140-83-4)
- Hydrochlorothiazide Impurity 1 (CAS 133-74-4)
- Hydrochlorothiazide Impurity 40 (CAS CATO-C4X-117740)
- Hydrochlorothiazide Impurity 41 (CAS CATO-C4X-117741)
- Hydrochlorothiazide Impurity 23 (CAS 19477-32-8)
- Hydrochlorothiazide Impurity 35 (CAS CATO-C4X-117735)
- Hydrochlorothiazide Impurity 36 (CAS CATO-C4X-117736)
Recommended Standards
- 37497-00-0 7H-Pyrimido(4,5-b)(1,4)thiazine, 6-amino-4-methoxy- 6-Amino-4-methoxy-7H-pyrimido(4,5-b)(1,4)thiazine BRN 0613793 (CAS 37497-00-0)
- Omeprazole Impurity 20 (CAS CATO-C4X-125520)
- 289-56-5 3-methyl-5-(methylsulfanyl)-2,4-dihydro-7h-pyrazolo[4,3-d]pyrimidin-7-one AR-1F4319 (CAS 289-56-5)
- 1-(1,2-dihydro-5-acenaphthylenyl)-1-ethanone (CAS 10047-18-4)
- Cefoperazone Impurity 33 (CAS CATO-C4X-114933)
- Osimertinib Impurity 60 (CAS CATO-C4X-204560)
- Levocarnitine impurity 31 (CAS CATO-C4X-129231)
- 4-[(2-N-Boc-Amino)-2-propyl]phenylboronic acid (CAS 2300953-19-7)
- Ethyl D-threoninate hydrochloride (CAS 62365-20-2)
- Ethyl 1-naphthoate (CAS 3007-97-4)
- 2-(tert-Butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-5-carboxylic acid (CAS 1251004-54-2)
- 2-{[5-(4-tert-butylphenyl)-4-ethyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide (CAS 893726-82-4)
- N-(3-Phenylpropyl)-2-(1H-1,2,4-triazol-1-yl)acetamide (CAS 866135-69-5)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788677)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com