Lumefantrine Impurity 1 CAS 1331642-68-2
| CAS No. | 1331642-68-2 |
| Molecular Formula | C30H32Cl3NO |
| Molecular Weight | 528.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Lumefantrine Impurity 1 (CAS 1331642-68-2, C30H32Cl3NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Lumefantrine Impurity 1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 528.94 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Lumefantrine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H32Cl3NO |
| Molecular Weight | 528.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lumefantrine Standards
- (9E)-Lumefantrine (CAS 1456736-33-6)
- LUMEFANTRINE (CAS 204133-10-8)
- Lumefantrine Impurity 14 (CAS 2170653-95-7)
- Lumefantrine (CAS 82186-77-4)
- Lumefantrine-d9 (Benflumetol-d9) (CAS 2477594-24-2)
- Lumefantrine D18 (CAS 1185240-53-2)
- Lumefantrine impurity 7 (CAS CATO-C4X-24267)
- Lumefantrine Impurity 6 (CAS 355841-11-1)
Recommended Standards
- (E)-1,2-bis(4-dodecylthiophen-2-yl)ethene (CAS 306769-54-0)
- ((2-Chloro-6-(methoxymethoxy)-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-yl)ethynyl)triisopropylsilane (CAS 2771460-20-7)
- Tolvaptan Impurity 50 (CAS 942619-74-1)
- PSB 603 (CAS 1092351-10-4)
- Clofazimine Impurity 18 (CAS CATO-C4X-207118)
- Nitroso Perindopril EP impurity Z (CAS CATO-C4X-125263)
- Hydrochlorothiazide Impurity 6 (CAS 23141-82-4)
- 1-Amino-3-(3-nitrophenyl)propane (CAS 238431-54-4)
- 1-(4-(Tert-butyl)benzyl)cyclopropan-1-amine (CAS 1017321-34-4)
- [5-(propan-2-yloxy)pyridin-2-yl]methanol (CAS 1198166-00-5)
- 4-(4-Fluorophenyl)thiazole-2-carboxylic acid (CAS 886366-96-7)
- 1-Benzyl-2-phenyl-1H-pyrrol-3(2H)-one (CAS 118060-73-4)
- Ethyl 2-Aminopyrrole-3-carboxylate (CAS 108290-86-4)
- Peptide Impurity 28 (CAS 1350456-64-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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