Tenofovir alafenamide impurity 75 CAS 379270-36-7
| CAS No. | 379270-36-7 |
| Molecular Formula | C21H29N6O5P |
| Molecular Weight | 476.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tenofovir alafenamide impurity 75 (CAS 379270-36-7) is a certified pharmaceutical impurity reference standard with the molecular formula C21H29N6O5P and a molecular weight of 476.47 g/mol.
Tenofovir alafenamide impurity 75 (C21H29N6O5P) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tenofovir alafenamide impurity 75 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H29N6O5P |
| Molecular Weight | 476.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir alafenamide Impurity 33 (CAS CATO-C4X-179733)
- Tenofovir alafenamide Impurity 42 (CAS 2053424-82-9)
- Tenofovir alafenamide Impurity 44 (CAS CATO-C4X-179744)
- Tenofovir alafenamide Impurity 45 (CAS CATO-C4X-179745)
- Tenofovir alafenamide Impurity 52 (CAS 383365-04-6)
- Tenofovir alafenamide (CAS 379270-37-8)
- Tenofovir alafenamide Impurity 62 (CAS CATO-C4X-179762)
- Tenofovir alafenamide impurity 74 (CAS 2053424-88-5)
Recommended Standards
- Tenofovir alafenamide Impurity 8 (CAS CATO-C4X-17978)
- Tenofovir alafenamide impurity 86 (CAS CATO-C4X-179786)
- Tenofovir alafenamide impurity 87 (CAS CATO-C4X-179787)
- Tenofovir alafenamide Impurity 97 (CAS CATO-C4X-179797)
- Flunarizine impurity 34 (CAS CATO-C4X-135734)
- Avibactam impurity 153 (CAS CATO-C4X-1348153)
- Voriconazole Impurity N2 (CAS 168479-96-7)
- 2-Bromo-2-methylpropanoic anhydride (CAS 42069-15-8)
- Pemetrexed EP Impurity E Disodium Salt (CAS 937370-10-0)
- 2-(2-(Trifluoromethyl)-1H-indol-3-yl)acetonitrile (CAS 174907-40-5)
- 6-((2,2,2-Trifluoroethyl)amino)nicotinic acid (CAS 1019388-10-3)
- 7-Isopropoxy-2-phenylquinolin-4-ol (CAS 825620-18-6)
- Roxadustat Impurity 101 (CAS CATO-C4X-2213101)
- HA Peptide (CAS 92000-76-5)
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