Nilotinib Impurity 44 CAS CATO-C4X-125644
| CAS No. | CATO-C4X-125644 |
| Molecular Formula | C24H18F3N5O |
| Molecular Weight | 449.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Nilotinib Impurity 44 (CAS CATO-C4X-125644), a pharmacopoeial impurity reference standard (molecular formula C24H18F3N5O, MW 449.43 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C24H18F3N5O, Nilotinib Impurity 44 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 449.43 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H18F3N5O |
| Molecular Weight | 449.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Nilotinib Standards
- Nilotinib Impurity A (CAS 1345336-53-9)
- Nilotinib Iodo Impurity (CAS 926922-18-1)
- Nilotinib Genotoxic Impurity 2 (CAS 1157857-29-8)
- Nilotinib EP Impurity E (CAS 2119583-26-3)
- Nilotinib Impurity 19 (CAS 915711-42-1)
- Nilotinib Impurity 42 (CAS CATO-C4X-125642)
- Nilotinib Hydrochloride Monohydrate EP Impurity H (CAS 641571-15-5)
- Nilotinib (CAS 641571-10-0)
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