Brimonidine Impurity 22 CAS 134892-46-9
| CAS No. | 134892-46-9 |
| Molecular Formula | C9H4BrN3S |
| Molecular Weight | 266.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Brimonidine Impurity 22 (CAS 134892-46-9, C9H4BrN3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Brimonidine Impurity 22 (C9H4BrN3S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 266.12 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H4BrN3S |
| Molecular Weight | 266.12 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Brimonidine Standards
- Brimonidine EP Impurity E (CAS 168329-48-4)
- Brimonidine Impurity 42 (CAS CATO-C4X-156642)
- Brimonidine EP Impurity D (CAS 842138-74-3)
- Brimonidine Impurity 20 (CAS 1217439-05-8)
- Brimonidine Related Impurity 4 (CAS 182628-02-0)
- Brimonidine Impurity 15 (CAS 91147-46-5)
- Brimonidine Impurity 24 (CAS CATO-C4X-156624)
- Brimonidine Impurity 25 (CAS 135306-57-9)
Recommended Standards
- Diclofenac potassium Impurity 7 (CAS CATO-C4X-10517)
- Urapidil Impurity 97 (CAS CATO-C4X-192497)
- Diclofenac EP Impurity B (CAS 22121-58-0)
- 4-(4-Bromophenyl)oxane-4-carbonitrile (CAS 1000705-54-3)
- Aripiprazole Impurity 12 (CAS 52749-50-5)
- Loxoprofen Impurity 70 (CAS 1027957-36-3)
- Cefditoren Impurity 14 (CAS CATO-C4X-135814)
- Methyl 2-amino-3-(benzyloxy)propanoate (CAS 55895-87-9)
- Methyl 2-(N-((4-(difluoromethoxy)-6-methylpyrimidin-2-yl)carbamoyl)sulfamoyl)benzoate (CAS 87474-61-1)
- 6,7-Dimethoxy-2-phenethyl-4H-chromen-4-one (CAS 84294-87-1)
- Ethyl 3-(4-Bromo-2-fluorophenyl)propanoate (CAS 1057674-14-2)
- Etozolin HCl (CAS 53-90-7)
- 3-Chloro-2-fluoro-6-methylaniline (CAS 1781007-03-1)
- D-Ala21-Tirzepatide (CAS CATO-CPTD788913)
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