(5Z)-Pioglitazone EP Impurity B CAS 136401-69-9
| CAS No. | 136401-69-9 |
| Molecular Formula | C19H18N2O3S |
| Molecular Weight | 354.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
(5Z)-Pioglitazone EP Impurity B (C19H18N2O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
(5Z)-Pioglitazone EP Impurity B (CAS 136401-69-9) is a certified pharmaceutical impurity reference standard with the molecular formula C19H18N2O3S and a molecular weight of 354.42 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), (5Z)-Pioglitazone EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H18N2O3S |
| Molecular Weight | 354.42 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Z Standards
- Pioglitazone impurity 38 (CAS CATO-C4X-138338)
- Pioglitazone Impurity 6 (CAS 144809-28-9)
- Pioglitazone Impurity 21 (CAS 105355-26-8)
- Pioglitazone impurity 25 (CAS CATO-C4X-138325)
- Pioglitazone impurity 31 (CAS CATO-C4X-138331)
- Pioglitazone (CAS 111025-46-8)
- Pioglitazone impurity 53 (CAS CATO-C4X-138353)
- Pioglitazone impurity 58 (CAS CATO-C4X-138358)
Recommended Standards
- tert-butyl N-(tert-butoxycarbonylamino)-N-(4-fluoro-3,5-dimethyl-phenyl)carbamate (CAS 2212021-55-9)
- Tert-butyl 4-(3-(4-fluorophenoxy)-2-hydroxypropyl)piperazine-1-carboxylate (CAS 874801-05-5)
- tert-Butyl 3-((4-carbamoylphenyl)sulfonyl)pyrrolidine-1-carboxylate (CAS 887587-88-4)
- Biotin Impurity 36 (CAS 1535184-53-2)
- Posaconazole Impurity 13(R,R,R,R) (CAS 170985-61-2)
- Udenafil Impurity N45 (CAS 936951-20-1)
- Esomeprazole Impurity 48 (CAS CATO-C4X-111248)
- Sodium 4-undecanoyl-1H-pyrrole-2-carboxylate (CAS 1007029-01-7)
- [4,4'-Biimidazolylidene]-5,5'(1H,1'H)-dione (CAS 873378-45-1)
- 4-(Methyl-d (CAS 86270-92-0)
- 4-Bromo-5,6-difluoroquinoline (CAS 1215770-44-7)
- 2-Bromo-5-(bromomethyl)-4-methylthiazole (CAS 1011532-22-1)
- N-Ethylcarbazole Impurity 1 (CAS 1088098-21-8)
- Semaglutide Impurity 75 (CAS CATO-C4X-2226175)
Why CATO?
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