Flurbiprofen EP Impurity E CAS 137045-30-8
| CAS No. | 137045-30-8 |
| Molecular Formula | C13H9FO2 |
| Molecular Weight | 216.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Flurbiprofen EP Impurity E (CAS 137045-30-8, C13H9FO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H9FO2, Flurbiprofen EP Impurity E contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 216.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Flurbiprofen EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9FO2 |
| Molecular Weight | 216.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 37 (CAS 56430-67-2)
- Flurbiprofen EP Impurity D (CAS 42771-79-9)
- Flurbiprofen Impurity 57 (CAS 81937-32-8)
- Flurbiprofen Impurity 162 (CAS 861795-19-9)
- Flurbiprofen Impurity 79 (CAS CATO-C4X-144479)
- Flurbiprofen Impurity 90 (CAS 145983-05-7)
- Flurbiprofen Impurity 61 (CAS 95037-98-2)
- Flurbiprofen Impurity 85 (CAS CATO-C4X-144485)
Recommended Standards
- Furosemide Impurity 41 (CAS 137-65-5)
- Clavulanic Acid Methyl-d3 Ester (CAS CATO-C4X-150116)
- Pantoprazole EP Impurity C (CAS 97963-62-7)
- Pazopanib Impurity 21 (CAS 6269-91-6)
- Clethodim Impurity 21 Chloride (CAS 194805-30-6)
- Bromfenac Impurity 23 (CAS 51135-38-7)
- Macitentan Impurity 15 (CAS 1642873-04-8)
- (6-Nitro-1,3-benzodioxol-5-yl)methyl 4-fluorobenzenecarboxylate (CAS 331460-21-0)
- Schradan (CAS 152-16-9)
- Baricitinib Impurity 20 (CAS 1187595-85-2)
- 5-METHYLISATOIC ANHYDRIDE (CAS 4692-99-3)
- 2-Methyl-4-[2-(1-piperidinyl)ethoxy]phenylamine (CAS 925920-77-0)
- 1-(2-Methylthiazol-5-yl)ethanone (CAS 43040-02-4)
- Galanin-Like Peptide (rat) trifluoroacetate salt (CAS 245114-97-0)
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