Valsartan Impurity 53 CAS 137863-42-4
| CAS No. | 137863-42-4 |
| Molecular Formula | C26H34N6O2 |
| Molecular Weight | 462.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Valsartan Impurity 53 (CAS 137863-42-4) is a certified pharmaceutical impurity reference standard with the molecular formula C26H34N6O2 and a molecular weight of 462.59 g/mol.
Structurally, Valsartan Impurity 53 (C26H34N6O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 462.59 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Valsartan Impurity 53 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H34N6O2 |
| Molecular Weight | 462.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 6 |
Related Valsartan Standards
- Valsartan Impurity 115 (CAS CATO-C4X-1057115)
- Valsartan Impurity 9 (CAS 1111177-30-0)
- Valsartan Impurity 114 (CAS CATO-C4X-1057114)
- Valsartan Impurity 139 (CAS 72907-79-0)
- Valsartan N-Oxide 2 (CAS CATO-C4X-1057148)
- Valsartan Impurity 149 (CAS CATO-C4X-1057149)
- Valsartan Impurity 4 (Mixture of Diastereomers) (CAS 188259-69-0)
- Valsartan N-Oxide (CAS CATO-C4X-105779)
Recommended Standards
- 2-((4-Allyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-(benzyloxy)phenyl)acetamide (CAS 573705-89-2)
- Palbociclib Impurity 189 (CAS CATO-C4X-1125189)
- 2-((1S)-9-Phosphabicyclo[4.2.1]nonan-9-ylmethyl)-2'-(9-phosphabicyclo[4.2.1]nonan-9-ylmethyl)-1,1'-biphenyl (CAS 525602-68-0)
- Fluocortolone Pivalate EP Impurity D (CAS CATO-C4X-223014)
- Bromfenac Impurity 73 (CAS CATO-C4X-200273)
- Ezetimibe Impurity 131 (CAS CATO-C4X-1098131)
- Dotinurad Impurity 49 (CAS CATO-C4X-249449)
- 5-Chloro-3-(trifluoromethyl)benzene-1,2-diamine (CAS 156425-10-4)
- 4-Benzhydryl-N-(2-fluorophenyl)piperazine-1-carboxamide (CAS 893340-18-6)
- (S)-4,4-Difluoro-1-glycylpyrrolidine-2-carbonitrile 4-methylbenzenesulfonate (CAS 1584652-36-7)
- Ethyl 2-Amino-6-butanoyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate (CAS 1148027-17-1)
- 5-Acetoxy-2-chlorobenzoic acid (CAS 1565758-62-4)
- rel-(1R,2S,5S)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride (CAS 73836-88-1)
- Experimental Allergic Encephalitogenic Peptide (CAS 29705-92-8)
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