Valsartan Impurity 120 CAS 137863-48-0
| CAS No. | 137863-48-0 |
| Molecular Formula | C25H31N5O3 |
| Molecular Weight | 449.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Valsartan Impurity 120 (CAS 137863-48-0, C25H31N5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Valsartan Impurity 120 (C25H31N5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 449.55 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C25H31N5O3 |
| Molecular Weight | 449.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 5 |
Related Valsartan Standards
- Valsartan Impurity 106 (CAS CATO-C4X-1057106)
- Valsartan Impurity 112 (CAS CATO-C4X-1057112)
- Valsartan Impurity 125 (CAS 1894176-40-9)
- Valsartan USP Related Compound E (CAS 137863-17-3)
- Valsartan Impurity 73 (CAS CATO-C4X-105773)
- Valsartan Impurity 74 (CAS CATO-C4X-105774)
- Valsartan Impurity 75 (CAS CATO-C4X-105775)
- Valsartan Impurity 76 (CAS CATO-C4X-105776)
Recommended Standards
- CAS CATO-C3D-4200 (CAS CATO-C3D-4200)
- ICA-121431, >98% (HPLC) (CAS 313254-51-2)
- Cholesteryl Bromide (CAS 516-91-6)
- 6-N-Biotinylaminohexyl isopropyl hydrogenphosphonate, 96% (CAS 224583-37-3)
- Polymyxin Impurity 56 X Trifluoroacetate (CAS 3034660-94-8 (free base))
- Flunarizine EP Impurity A (CAS 27469-60-9)
- Parecoxib Impurity 22 (CAS 139395-94-1)
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- Ethyl 3-(3-hydroxyphenyl)acrylate (CAS 3943-96-2)
- N-(4-(Methylthio)phenyl)-3-phenylpropanamide (CAS 27816-91-7)
- Methyl 2-((3-fluorobenzyl)oxy)-5-(2-methylthiazol-4-yl)benzoate (CAS 1416344-76-7)
- 1-((4-Ethoxy-5-isopropyl-2-methylphenyl)sulfonyl)azepane (CAS 898654-55-2)
- 1-Chloro-2-ethynyl-4-(trifluoromethyl)benzene (CAS 148258-94-0)
- Insulin Degludec Impurity 18 (CAS CATO-C4X-215718)
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