Tolvaptan Impurity 99 CAS 137977-35-6
| CAS No. | 137977-35-6 |
| Molecular Formula | C25H21ClN2O3 |
| Molecular Weight | 432.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tolvaptan Impurity 99 (CAS 137977-35-6, C25H21ClN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tolvaptan Impurity 99 (C25H21ClN2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H21ClN2O3 |
| Molecular Weight | 432.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tolvaptan Standards
- Tolvaptan Impurity 41 (CAS 1580889-32-2)
- Tolvaptan Impurity 40 (CAS 176970-21-1)
- Tolvaptan Impurity 23 (CAS 1580889-33-3)
- Tolvaptan Impurity 24 (CAS 150683-27-5)
- Tolvaptan Impurity 4 (CAS 1133419-00-7)
- Tolvaptan Impurity 14 (CAS 137973-76-3)
- Tolvaptan Impurity 67 (CAS 1580889-26-4)
- Tolvaptan Impurity 68 (CAS 1580889-24-2)
Recommended Standards
- Sivelestat Impurity 33 (CAS CATO-C4X-212333)
- Purvalanol B (CAS 212844-54-7)
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- 1,5-Diethyl (2E,4E)-4-{amino[4-(4-chlorophenyl)piperazin-1-yl]methylidene}-2-cyanopent-2-enedioate (CAS 338406-34-1)
- Mirtazapine Impurity 28 HCl (CAS CATO-C4X-151128)
- Alogliptin Impurity 49 (CAS 655-63-0)
- Ibrutinib Impurity 177 (CAS CATO-C4X-1064177)
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- 4-(2,2,2-Trifluoroethoxy)picolinic acid (CAS 886372-43-6)
- Tedizolid impurity 102 (CAS 890051-54-4)
- Methyl (R)-3-(methylamino)-2,3-dihydro-1H-indene-5-carboxylate (CAS 1246505-79-2)
- Selenopheno[2,3-b]selenophene (CAS 250-85-1)
- Semaglutide impurity 91 (CAS CATO-C4X-222691)
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