Abemaciclib impurity 107 CAS 1383745-09-2
| CAS No. | 1383745-09-2 |
| Molecular Formula | C8H6BrF2NO |
| Molecular Weight | 250.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Abemaciclib impurity 107 (CAS 1383745-09-2) is a certified pharmaceutical impurity reference standard with the molecular formula C8H6BrF2NO and a molecular weight of 250.04 g/mol.
Structurally, Abemaciclib impurity 107 (C8H6BrF2NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 250.04 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6BrF2NO |
| Molecular Weight | 250.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Abemaciclib Standards
- Abemaciclib Impurity 100 (CAS 658072-14-1)
- Abemaciclib Impurity 180 (CAS CATO-C4X-2937180)
- Abemaciclib Impurity N5 (CAS 1038408-36-4)
- Abemaciclib Impurity 38 (CAS CATO-C4X-293738)
- Abemaciclib Impurity 187 (CAS CATO-C4X-2937187)
- Abemaciclib Impurity 147 (CAS 2189739-28-2)
- Abemaciclib Impurity 158 (CAS CATO-C4X-2937158)
- Abemaciclib Impurity 173 (CAS CATO-C4X-2937173)
Recommended Standards
- Enarodustat Impurity 18 (CAS CATO-C4X-322818)
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- Nadifloxacin Impurity 15 (CAS 64695-81-4)
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- Peramivir Impurity 115 (CAS CATO-C4X-1833115)
- 8-Bromo-3,3-dimethyl-3,4-dihydroquinolin-2(1h)-one (CAS 2167942-69-8)
- 4,4'-(((9H-Fluorene-9,9-diyl)bis(4,1-phenylene))bis(oxy))dianiline (CAS 47823-88-1)
- (3-Bromo-2,6-dimethylphenyl)methanol (CAS 86246-72-2)
- (2,5-Difluorophenyl)(piperidin-4-yl)methanol (CAS 1094340-95-0)
- β-D-Lactopyranosylphenyl isothiocyanate (CAS 96324-93-5)
- a-Amino-1-methyl-cyclohexaneacetic acid (CAS 855417-33-3)
- [D-Ser8]-Semaglutide A (CAS CATO-C4X-2226116)
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