Abemaciclib Impurity 100 CAS 658072-14-1
| CAS No. | 658072-14-1 |
| Molecular Formula | C8H6BrF2NO |
| Molecular Weight | 250.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Abemaciclib Impurity 100 (CAS 658072-14-1), a pharmacopoeial impurity reference standard (molecular formula C8H6BrF2NO, MW 250.04 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, Abemaciclib Impurity 100 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 250.04 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Abemaciclib Impurity 100 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H6BrF2NO |
| Molecular Weight | 250.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Abemaciclib Standards
- Abemaciclib impurity 107 (CAS 1383745-09-2)
- Abemaciclib Impurity 180 (CAS CATO-C4X-2937180)
- Abemaciclib Impurity N5 (CAS 1038408-36-4)
- Abemaciclib Impurity 38 (CAS CATO-C4X-293738)
- Abemaciclib Impurity 187 (CAS CATO-C4X-2937187)
- Abemaciclib Impurity 147 (CAS 2189739-28-2)
- Abemaciclib Impurity 158 (CAS CATO-C4X-2937158)
- Abemaciclib Impurity 173 (CAS CATO-C4X-2937173)
Recommended Standards
- Resmetirom impurity 55 (CAS 17742-65-3)
- Nadifloxacin Impurity 15 (CAS 64695-81-4)
- Enarodustat Impurity 18 (CAS CATO-C4X-322818)
- Perfluoropent-2-ene (CAS 58349-49-8)
- Mosapride Impurity 33 (CAS 116143-27-2)
- Fluocinolone Acetonide EP Impurity B (CAS 65751-34-0)
- Pioglitazone impurity 37 (CAS CATO-C4X-138337)
- 1,3,5-Tris(terphenyl)-benzene (CAS 1246015-42-8)
- N-((1-Ethyl-1H-pyrazol-4-yl)methyl)-1-(2-fluoroethyl)-5-methyl-1H-pyrazol-4-amine hydrochloride (CAS 1855951-95-9)
- Ethyl 4-(((tert-butoxycarbonyl)(methyl)amino)methyl)benzoate (CAS 1823521-16-9)
- (R)-(+)-1,1＇-Bi-2-naphthol (CAS 18531-94-7)
- 4-Chloro-N-(4-fluorobenzyl)picolinamide (CAS 851441-84-4)
- Resmetirom Impurity 27 (CAS CATO-C4X-291227)
- Fragment-[9-31]-Semaglutide (CAS CATO-C4X-2226181)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com