Abemaciclib Impurity 187 CAS CATO-C4X-2937187
| CAS No. | CATO-C4X-2937187 |
| Molecular Formula | C12H11Cl2N2 |
| Molecular Weight | 254.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Abemaciclib Impurity 187 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Abemaciclib Impurity 187 (CAS CATO-C4X-2937187, C12H11Cl2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Abemaciclib Impurity 187 (C12H11Cl2N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C12H11Cl2N2 |
| Molecular Weight | 254.14 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib Impurity N5 (CAS 1038408-36-4)
- Abemaciclib Impurity 147 (CAS 2189739-28-2)
- Abemaciclib Impurity 180 (CAS CATO-C4X-2937180)
- Abemaciclib Impurity 158 (CAS CATO-C4X-2937158)
- Abemaciclib Impurity 100 (CAS 658072-14-1)
- Abemaciclib impurity 107 (CAS 1383745-09-2)
- Abemaciclib Impurity 38 (CAS CATO-C4X-293738)
- Abemaciclib Impurity 164 (CAS CATO-C4X-2937164)
Recommended Standards
- Ticagrelor Impurity 115 (CAS 1823431-32-8)
- 2-Bromo-4-(p-tolyl)thiazole (CAS 101862-33-3)
- 3-Nitro-2-(2,2,3,3-tetrafluoropropoxy)pyridine (CAS 1980049-92-0)
- 1-(4-Ethoxy-3,5-difluorophenyl)-2,2,2-trifluoroethan-1-one (CAS 115467-03-3)
- Salbutamol Sulfate EP Impurity L (CAS 898542-81-9)
- Ferulic Acid Impurity 3 (CAS 948051-11-4)
- Selumetinib Impurity 6 (CAS CATO-C4X-30536)
- 2',3'-Dideoxy-2'-fluorouridine (CAS 122929-22-0)
- 1-((1H-pyrazol-1-yl)methyl)-5-methyl-1H-pyrazol-3-amine (CAS 1006472-91-8)
- Noformycin (CAS 155-38-4)
- 2,2-Diethoxypropan-1-amine (CAS 39550-25-9)
- 5-Fluoro-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline (CAS 625127-11-9)
- Methyl 2-(isopropylamino)benzoate (CAS 17318-50-2)
- Semaglutide impurity 87 (CAS CATO-C4X-222687)
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