Agomelatine Impurity 3 CAS 1385018-57-4
| CAS No. | 1385018-57-4 |
| Molecular Formula | C26H27NO2 |
| Molecular Weight | 385.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Agomelatine Impurity 3 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Agomelatine Impurity 3 (CAS 1385018-57-4) is a certified pharmaceutical impurity reference standard with the molecular formula C26H27NO2 and a molecular weight of 385.50 g/mol.
Agomelatine Impurity 3 (C26H27NO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H27NO2 |
| Molecular Weight | 385.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Agomelatine Standards
- Agomelatine Impurity 9 (CAS CATO-C4X-11089)
- Agomelatine Impurity 4 (CAS CATO-C4X-11084)
- Agomelatine impurity 31 (CAS CATO-C4X-110831)
- Agomelatine Impurity 1 (CAS 1385018-58-5)
- Agomelatine Impurity 2 (CAS 185421-27-6)
- Agomelatine Diacetyl Impurity (CAS 1379005-34-1)
- Agomelatine Impurity 53 (CAS CATO-C4X-110853)
- Agomelatine Impurity 28 (CAS CATO-C4X-110828)
Recommended Standards
- 4'-((2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-2-en-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile (CAS CATO-C3D-2418)
- Rosuvastatin Impurity 89 (CAS CATO-C4X-116989)
- JWH-098 ((4-Methoxynaphthalen-1-yl)(2-methyl-1-pentylindol-3-yl)methanone) 1.0 mg/ml in Acetonitrile (4-methoxynaphthalen-1-yl)-(2-methyl-1-pentylindol-3-yl)methanone (4-Methoxynaphthalen-1-yl)(2-methyl-1-pentylindol-3-yl)methanone 316189-74-9 (CAS 316189-74-9)
- Buspirone (CAS 36505-84-7)
- Prucalopride Impurity 9 (CAS 182808-16-8)
- Delamanid Impurity 5 (CAS 1194254-67-5)
- Relugolix Impurity 160 (CAS CATO-C4X-2429160)
- Spiropyran 1 (CAS 1253909-21-5)
- 3,3'-(1,2,4,5-Tetrazine-3,6-diyl)dibenzoic acid (CAS 856055-91-9)
- 4-(4-Bromophenyl)-2-phenylthiomorpholine-3,5-dione (CAS 339098-41-8)
- 3-Bromo-7-fluoro-5-methoxy-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide (CAS 2100839-76-5)
- 3-(3,5-Dimethylphenoxy)piperidine 4015AF 946681-15-8 C13H19NO (CAS 946681-15-8)
- 7-Chloro-3-(2-fluorobenzyl)quinazolin-4(3H)-one (CAS 302913-39-9)
- Peptide 437 (CAS CATO-CPTD788437)
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