Bromfenac Impurity 3 CAS 1391052-54-2
| CAS No. | 1391052-54-2 |
| Molecular Formula | C15H9BrNO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 370.13 g/mol gives Bromfenac Impurity 3 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Bromfenac Impurity 3 (CAS 1391052-54-2) is a certified pharmaceutical impurity reference standard with the molecular formula C15H9BrNO4Na and a molecular weight of 370.13 g/mol.
The molecular framework of Bromfenac Impurity 3 (C15H9BrNO4Na) is characterized by a salt form, a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H9BrNO4 Na |
| Molecular Weight | 370.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Bromfenac Standards
- Bromfenac Impurity 30 (CAS 102414-22-2)
- Bromfenac Sodium Sesquihydrate (CAS 120638-55-3)
- Bromfenac Impurity 30 (CAS 1279501-08-4)
- Bromfenac Impurity 76 (CAS 1623751-93-8)
- Bromfenac Impurity 33 (CAS 1644279-16-2)
- Bromfenac Impurity N2 (CAS 1798431-98-7)
- Bromfenac N-β-D-Glucoside (CAS 212266-82-5)
- Bromfenac Impurity 41 (CAS 2192334-72-6)
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