Loperamide EP Impurity A CAS 1391052-94-0
| CAS No. | 1391052-94-0 |
| Molecular Formula | C35H37ClN2O2 |
| Molecular Weight | 553.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Loperamide EP Impurity A (CAS 1391052-94-0), a pharmacopoeial impurity reference standard (molecular formula C35H37ClN2O2, MW 553.13 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Loperamide EP Impurity A (C35H37ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 18.0, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 553.13 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Loperamide EP Impurity A under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C35H37ClN2O2 |
| Molecular Weight | 553.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loperamide Standards
- Loperamide EP Impurity G (CAS 109572-89-6)
- Loperamide N-Oxide (CAS 217471-03-9)
- Loperamide EP Impurity G (CAS CATO-C4X-178810)
- Loperamide EP Impurity F (CAS 106900-12-3)
- Loperamide impurity 12 (CAS CATO-C4X-178812)
- Loperamide (CAS 53179-11-6)
- Loperamide EP Impurity E (CAS 1426322-82-8)
- Loperamide EP Impurity H (CAS 61299-42-1)
Recommended Standards
- 5-(4-Chlorophenyl)-2-{[(3,5-dimethylphenyl)methyl]sulfanyl}-4-{2'-fluoro-4'-propyl-[1,1'-biphenyl]-4-yl}pyrimidine (CAS 478248-98-5)
- (R)-3,3'-Dibromo-1,1'-Binaphthalene-2,2'-sulfonimide (CAS 1245748-52-0)
- 2'-(2-Chloroanilino)-6'-(dibutylamino)fluoran (CAS 82137-81-3)
- (S)-3,3'-Dibromo-1,1'-Binaphthalene-2,2'-sulfonimide (CAS 1461735-85-2)
- Azilsartan Impurity 126 (CAS 1604812-36-3)
- Lovastatin Impurity 34 (CAS CATO-C4X-168434)
- Olanexidine Impurity 2 (CAS CATO-C4X-22832)
- 2-(2-Fluoro-5-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2379792-68-2)
- 1-(5-Amino-1-methyl-1H-benzo[d]imidazol-2-yl)ethan-1-ol (CAS 799260-16-5)
- LPA2 Antagonist 1 (CAS 1017606-66-4)
- 2-(3,4-Dimethylphenyl)benzo[d]oxazol-5-amine (CAS 352338-21-7)
- (R)-2-amino-5-(methylthio)pentanoic acid (CAS 108691-69-6)
- 5-(Pyridin-3-yl)isoxazole-4-carboxylic acid (CAS 954230-79-6)
- Semaglutide impurity 261 (CAS CATO-C4X-2226261)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com