Loperamide EP Impurity F CAS 106900-12-3
| CAS No. | 106900-12-3 |
| Molecular Formula | C29H33ClN2O3 |
| Molecular Weight | 493.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C29H33ClN2O3, Loperamide EP Impurity F contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 493.04 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Loperamide EP Impurity F (CAS 106900-12-3), a pharmacopoeial impurity reference standard (molecular formula C29H33ClN2O3, MW 493.04 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Loperamide EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H33ClN2O3 |
| Molecular Weight | 493.04 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loperamide Standards
- Loperamide EP Impurity G (CAS 109572-89-6)
- Loperamide N-Oxide (CAS 217471-03-9)
- Loperamide EP Impurity G (CAS CATO-C4X-178810)
- Loperamide impurity 12 (CAS CATO-C4X-178812)
- Loperamide (CAS 53179-11-6)
- Loperamide EP Impurity H (CAS 61299-42-1)
- Loperamide Impurity 16 (CAS CATO-C4X-178816)
- Loperamide EP Impurity D (CAS 37743-41-2)
Recommended Standards
- 2-{[(3-chlorophenyl)methyl]sulfanyl}-6-[(E)-2-(4-methylphenyl)ethenyl]-4-[(Z)-2-(4-methylphenyl)ethenyl]pyridine-3-carbonitrile (CAS 303985-41-3)
- 2-{[(4-chlorophenyl)methyl]sulfanyl}-6-[(E)-2-(4-methylphenyl)ethenyl]-4-[(Z)-2-(4-methylphenyl)ethenyl]pyridine-3-carbonitrile (CAS 303985-42-4)
- trans-Dichlorobis(4-chloropyridine)platinum (CAS 24476-74-2)
- Betamethasone Valerate EP Impurity H (CAS 52619-18-8)
- CAS 1654008-88-4 (CAS 1654008-88-4)
- Cefalotin EP Impurity B (CAS 5935-65-9)
- Cinepazide Impurity 3 (CAS CATO-C4X-18153)
- 6-Bromo-3-chloroquinoxalin-2-amine (CAS 1083181-47-8)
- Methyl 4-(((tert-butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylate (CAS 1609407-74-0)
- tert-Butyl ((5-amino-4-formylpyridin-3-yl)methyl)carbamate (CAS 1393574-75-8)
- Ethyl 2,4-dioxo-3-(3-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]Hexane-6-carboxylate (CAS 318237-87-5)
- 2-Hydroxyphenyl 3-methoxybenzoate (CAS 5876-99-3)
- 2-fluorocyclobutanamine hydrochloride (CAS 2288709-22-6)
- [3-31]-Semaglutide D (CAS C152H230N42O47)
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