Loperamide EP Impurity E CAS 1426322-82-8
| CAS No. | 1426322-82-8 |
| Molecular Formula | C38H40Cl2N2O3 |
| Molecular Weight | 643.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Loperamide EP Impurity E is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 643.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Loperamide EP Impurity E (CAS 1426322-82-8), a pharmacopoeial impurity reference standard (molecular formula C38H40Cl2N2O3, MW 643.64 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Loperamide EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C38H40Cl2N2O3 |
| Molecular Weight | 643.64 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loperamide Standards
- Loperamide EP Impurity A (CAS 1391052-94-0)
- Loperamide EP Impurity G (CAS 109572-89-6)
- Loperamide N-Oxide (CAS 217471-03-9)
- Loperamide EP Impurity G (CAS CATO-C4X-178810)
- Loperamide EP Impurity F (CAS 106900-12-3)
- Loperamide impurity 12 (CAS CATO-C4X-178812)
- Loperamide (CAS 53179-11-6)
- Loperamide EP Impurity H (CAS 61299-42-1)
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- ethyl 1H-pyrazolo[3,4-c]pyridine-3-carboxylate (CAS 1053656-33-9)
- (R)-3-Amino-3-(4-phenoxyphenyl)propan-1-ol (CAS 1212959-85-7)
- Calcipotriol EP Impurity E （and eantiomer） (CAS CATO-C4X-12225)
- 6-Amino-4-[4-(cyclopentyloxy)-3-methoxyphenyl]-3-(propan-2-yl)-2H,4H-pyrano[2,3-c]pyrazole-5-carbonitrile (CAS 825603-06-3)
- Semaglutide impurity 54 (CAS CATO-C4X-222654)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com