Loperamide impurity 12 CAS CATO-C4X-178812
| CAS No. | CATO-C4X-178812 |
| Molecular Formula | C28H30ClN3O3 |
| Molecular Weight | 492.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 492.01 g/mol gives Loperamide impurity 12 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Loperamide impurity 12 (CAS CATO-C4X-178812), a pharmacopoeial impurity reference standard (molecular formula C28H30ClN3O3, MW 492.01 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C28H30ClN3O3, Loperamide impurity 12 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 492.01 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H30ClN3O3 |
| Molecular Weight | 492.01 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Loperamide Standards
- Loperamide EP Impurity G (CAS 109572-89-6)
- Loperamide N-Oxide (CAS 217471-03-9)
- Loperamide EP Impurity G (CAS CATO-C4X-178810)
- Loperamide EP Impurity F (CAS 106900-12-3)
- Loperamide (CAS 53179-11-6)
- Loperamide EP Impurity H (CAS 61299-42-1)
- Loperamide Impurity 16 (CAS CATO-C4X-178816)
- Loperamide EP Impurity D (CAS 37743-41-2)
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