Ticagrelor impurity 21 CAS 1402222-66-5
| CAS No. | 1402222-66-5 |
| Molecular Formula | C9H9F2N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 205.63 g/mol gives Ticagrelor impurity 21 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ticagrelor impurity 21 (CAS 1402222-66-5) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9F2NHCl and a molecular weight of 205.63 g/mol.
Structurally, Ticagrelor impurity 21 (C9H9F2NHCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 205.63 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ticagrelor impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9F2N HCl |
| Molecular Weight | 205.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Ticagrelor Standards
- Ticagrelor Impurity N40 (CAS 1006376-60-8)
- Ticagrelor Impurity 88 (CAS 1006376-61-9)
- Ticagrelor Impurity 152 (CAS 1006376-62-0)
- Ticagrelor Impurity 121 (CAS 1006614-49-8)
- Ticagrelor impurity 84（trans） (CAS 1006614-51-2)
- Ticagrelor Impurity 113 (CAS 1156575-52-8)
- Ticagrelor impurity 161 (CAS 1157692-93-7)
- Ticagrelor Impurity 168 (CAS 1207276-00-3(free base))
Recommended Standards
- Abemaciclib Impurity 17 (CAS CATO-C4X-293717)
- Brinzolamide Impurity 11 (CAS CATO-C4X-194011)
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- 2,2'-(Chloromethylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 2831415-88-2)
- N-(3-(1H-Imidazol-1-yl)propyl)-4,5-dichloro-2-methylbenzenesulfonamide (CAS 838871-11-7)
- 1-Benzyl-3-(((tert-butyldimethylsilyl)oxy)methyl)piperidin-4-ol (CAS 934536-18-2)
- (2-Methylpiperidin-4-yl)methanamine (CAS 1236121-42-8)
- 4-Bromo-5-fluoro-2-nitrobenzonitrile (CAS 1527490-63-6)
- 6-(4-Fluorophenyl)pyrazin-2-amine (CAS 1159815-52-7)
- D-Phe22-Tirzepatide (CAS CATO-CPTD788912)
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