Regorafenib Impurity 65 CAS 1403469-80-6
| CAS No. | 1403469-80-6 |
| Molecular Formula | C7H6Cl2N2O |
| Molecular Weight | 205.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Regorafenib Impurity 65.
CATO supplies Regorafenib Impurity 65 (CAS 1403469-80-6), a pharmacopoeial impurity reference standard (molecular formula C7H6Cl2N2O, MW 205.04 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Regorafenib Impurity 65 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 205.04 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Regorafenib Impurity 65 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6Cl2N2O |
| Molecular Weight | 205.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Regorafenib Standards
- Regorafenib Impurity 20 (CAS 1379324-09-0)
- Regorafenib Impurity 30 (CAS CATO-C4X-104730)
- Regorafenib Impurity 47 (CAS 51488-21-2)
- Regorafenib Impurity 55 (CAS 18584-93-5)
- Regorafenib Impurity 45 (CAS 39893-50-0)
- Regorafenib Impurity 21 (CAS 88330-63-6)
- Regorafenib Impurity 61 (CAS 327-78-6)
- Regorafenib Impurity 49 (CAS 90048-09-2)
Recommended Standards
- Econazole Impurity 4 (CAS 137958-96-4)
- Tranexamic Impurity 19 (CAS 5278-91-1)
- 3-chloro-4-methoxybenzoyl chloride (CAS 36590-49-5)
- Guanfacine Hydrochloride Impurity 3 (CAS 6575-24-2)
- Vilanterol Impurity 55 (CAS CATO-C4X-193555)
- Dotinurad Impurity 185 (CAS CATO-C4X-2494185)
- Nebivolol Impurity 44 (CAS 197706-51-7)
- [6-cyclopropyl-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (CAS 937605-76-0)
- 6-Amino-2-((4-methoxyphenyl)amino)pyrimidin-4-ol (CAS 500861-70-1)
- 7-Bromo-2H-benzo[e][1,2,4]thiadiazine-3(4H)-thione 1,1-dioxide (CAS 114260-86-5)
- 1-(2-Fluorophenyl)-2-methyl-1h-pyrrole (CAS 1354784-00-1)
- 2-(3-Bromophenoxy)benzoic acid (CAS 1021245-85-1)
- Sodium (5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoyl)(methylsulfonyl)amide (CAS 108731-70-0)
- Insulin Degludec Impurity 16 (CAS CATO-C4X-215716)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com