Regorafenib Impurity 30 CAS CATO-C4X-104730
| CAS No. | CATO-C4X-104730 |
| Molecular Formula | C7H6Cl2N2O |
| Molecular Weight | 205.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 205.04 g/mol gives Regorafenib Impurity 30 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Regorafenib Impurity 30 (CAS CATO-C4X-104730, C7H6Cl2N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C7H6Cl2N2O, Regorafenib Impurity 30 contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 205.04 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6Cl2N2O |
| Molecular Weight | 205.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Regorafenib Standards
- Regorafenib Impurity 20 (CAS 1379324-09-0)
- Regorafenib Impurity 65 (CAS 1403469-80-6)
- Regorafenib Impurity 47 (CAS 51488-21-2)
- Regorafenib Impurity 55 (CAS 18584-93-5)
- Regorafenib Impurity 45 (CAS 39893-50-0)
- Regorafenib Impurity 21 (CAS 88330-63-6)
- Regorafenib Impurity 61 (CAS 327-78-6)
- Regorafenib Impurity 49 (CAS 90048-09-2)
Recommended Standards
- 3-chloro-4-methoxybenzoyl chloride (CAS 36590-49-5)
- Econazole Impurity 4 (CAS 137958-96-4)
- 3,4-Dichloro-5-methylbenzoic Acid (CAS 6660-60-2)
- Tranexamic Impurity 19 (CAS 5278-91-1)
- Mabuterol Impurity 4 (CAS CATO-C4X-14544)
- Lidocaine Impurity 83 (CAS CATO-C4X-167983)
- Cenobamate Impurity 53 (CAS CATO-C4X-241653)
- 4-Chloro-N-(2,6-dimethylphenyl)-2-methoxy-5-sulfamoylbenzamide (CAS 55488-66-9)
- Methyl 6-(2-aminophenyl)nicotinate (CAS 885277-03-2)
- Empagliflozin Impurity 281 (CAS 1096342-71-0)
- 5-Chloro-2,4-difluoro-6-methylpyrimidine (CAS 72630-78-5)
- 11-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)undecanoic acid (CAS 2499815-05-1)
- 5-(Acetamidomethyl)thiophene-2-sulfonyl chloride (CAS 859491-07-9)
- Acetyl decapeptide-3 (CAS 935288-50-9)
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