Everolimus Impurity 18 CAS 141392-23-6
| CAS No. | 141392-23-6 |
| Molecular Formula | C50H77NO13 |
| Molecular Weight | 900.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Everolimus Impurity 18 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Everolimus Impurity 18 (CAS 141392-23-6, C50H77NO13) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Everolimus Impurity 18 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 900.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C50H77NO13 |
| Molecular Weight | 900.15 g/mol |
| Purity | >80% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 1 |
Related Everolimus Standards
- Everolimus Impurity 15（Z&Emixture） (CAS 147438-27-5 (E-Isomer）)
- Everolimus Impurity 16 (CAS 147438-29-7)
- Everolimus Impurity 17 (CAS 253431-35-5)
- Everolimus EP Impurity A (CAS 53123-88-9)
- Everolimus EP Impurity A-d3 (CAS 392711-19-2)
- Everolimus Impurity 22 (CAS CATO-C4X-112222)
- Everolimus EP Impurity E (CAS 1237826-25-3)
- Everolimus Impurity 49 (CAS CATO-C4X-112249)
Recommended Standards
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- 42-O-Desmethyl Rapamycin (CAS 142382-16-9)
- Landiolol Impurity 96 (CAS CATO-C4X-262196)
- Iguratimod Impurity 15 HCl (CAS 149436-41-9)
- Lemborexant Impurity 68 (CAS CATO-C4X-304268)
- tert-Butyl (1-(ethylamino)-1-oxopropan-2-yl)carbamate (CAS 1101135-76-5)
- 3-Methyl-1-(3-nitrophenyl)butan-2-one (CAS 1402614-81-6)
- tert-Butyl (2R,4S)-2-ethynyl-4-hydroxypyrrolidine-1-carboxylate (CAS 833474-71-8)
- N-benzyl-1-methyl-1H-pyrazole-3-carboxamide (CAS 303066-25-3)
- 7-Methyl-3-(piperazin-1-ylcarbonyl)pyrazolo[1,5-a]pyridine (CAS 1428233-82-2)
- N-(1-(3-fluoropyridin-4-yl)ethyl)thietan-3-amine (CAS 1866519-77-8)
- [D-Glu]3-Semaglutide (CAS CATO-C4X-2226253)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com