Upadacitinib Impurity 182 CAS 1428243-39-3
| CAS No. | 1428243-39-3 |
| Molecular Formula | C15H18BrNO3 |
| Molecular Weight | 340.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Upadacitinib Impurity 182 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Upadacitinib Impurity 182 (CAS 1428243-39-3, C15H18BrNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Upadacitinib Impurity 182 (C15H18BrNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H18BrNO3 |
| Molecular Weight | 340.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Upadacitinib Standards
- Upadacitinib Impurity 140 (CAS CATO-C4X-2405140)
- Upadacitinib Impurity 141 (CAS CATO-C4X-2405141)
- Upadacitinib Impurity 57 (CAS CATO-C4X-240557)
- Upadacitinib Impurity 169 (CAS CATO-C4X-2405169)
- Upadacitinib Impurity 1 (CAS CATO-C4X-24051)
- Upadacitinib Impurity 60 (CAS 2650489-62-4)
- Upadacitinib Impurity 35 (CAS CATO-C4X-240535)
- Upadacitinib Impurity 113 (CAS CATO-C4X-2405113)
Recommended Standards
- Ivabradine Impurity 22 (CAS 1428869-91-3)
- 2-(4-(Benzyloxy)-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1000796-87-1)
- tert-Butyl 8-bromo-6-formyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 2893884-40-5)
- 2-(3-(Benzyloxy)-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1005010-03-6)
- Crizotinib impurity 18 (CAS 2322921-92-4)
- Tofacitinib Impurity 67 (CAS CATO-C4X-107967)
- Cabotegravir Impurity 8 (CAS 1646862-21-6)
- 5-(4-Methoxy-phenylsulfamoyl)-2-methyl-benzoic acid (CAS 406928-28-7)
- (E)-1-(2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3-(dimethylamino)prop-2-en-1-one (CAS 1189751-28-7)
- 4-(Cyclohexylthio)-3-nitrobenzoic acid (CAS 352523-83-2)
- 1-[(Pyrazin-2-yl)amino]propan-2-ol (CAS 866156-90-3)
- N-(4H-1,2,4-Triazol-4-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide (CAS 717872-62-3)
- 1-(3-Hydroxy-2-methoxypyridin-4-yl)ethan-1-one (CAS 1256809-86-5)
- D-Asp15-Tirzepatide (CAS CATO-CPTD788919)
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