Upadacitinib Impurity 1 CAS CATO-C4X-24051
| CAS No. | CATO-C4X-24051 |
| Molecular Formula | C13H18F3N5O2 |
| Molecular Weight | 333.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 333.31 g/mol gives Upadacitinib Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Upadacitinib Impurity 1 (CAS CATO-C4X-24051, C13H18F3N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Upadacitinib Impurity 1 (C13H18F3N5O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Upadacitinib Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H18F3N5O2 |
| Molecular Weight | 333.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Upadacitinib Standards
- Upadacitinib Impurity 140 (CAS CATO-C4X-2405140)
- Upadacitinib Impurity 141 (CAS CATO-C4X-2405141)
- Upadacitinib Impurity 57 (CAS CATO-C4X-240557)
- Upadacitinib Impurity 101 (CAS CATO-C4X-2405101)
- Upadacitinib Impurity 143 (CAS CATO-C4X-2405143)
- Upadacitinib Impurity 181 (CAS CATO-C4X-2405181)
- Upadacitinib Impurity 196 (CAS CATO-C4X-2405196)
- Upadacitinib Impurity 182 (CAS 1428243-39-3)
Recommended Standards
- Lomefloxacin Impurity 8 (CAS 195259-12-2)
- 1-(2-Fluorophenyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1011397-00-4)
- Norfloxacin Impurity 19 (CAS 74011-42-0)
- 1-(4-Fluorophenyl)-6-phenyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1011397-67-3)
- Mivacurium chloride Impurity 66 (CAS CATO-C4X-137566)
- Ioversol Impurity 24 (CAS CATO-C4X-209124)
- Probucol Impurity 12 (CAS 186503-04-8)
- 3-Amino-2-oxo-1,2,3,4-tetrahydroquinoline-8-carboxylic acid (CAS 733706-01-9)
- N-(4-(2,4-dichlorophenyl)thiazol-2-yl)-2-((2,5-dimethylphenyl)thio)acetamide (CAS 338957-94-1)
- 2-((4-Ethyl-5-propyl-4H-1,2,4-triazol-3-yl)thio)acetic acid (CAS 603071-16-5)
- 5-(2-Chloropyridin-3-yl)-3-(2,4-dimethylphenyl)-1,2,4-oxadiazole (CAS 1707727-34-1)
- methyl 6-(2-chloroacetamido)pyridine-2-carboxylate (CAS 1803601-20-8)
- Methyl 4-aminobenzofuran-2-carboxylate (CAS 1783586-99-1)
- Tirzepatide Impurity 50 (CAS CATO-C4X-324050)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com