Gemcitabine Impurity 16 CAS 1173824-58-2
| CAS No. | 1173824-58-2 |
| Molecular Formula | C19H16F2O6 |
| Molecular Weight | 378.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Gemcitabine Impurity 16 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Gemcitabine Impurity 16 (CAS 1173824-58-2) is a certified pharmaceutical impurity reference standard with the molecular formula C19H16F2O6 and a molecular weight of 378.32 g/mol.
Structurally, Gemcitabine Impurity 16 (C19H16F2O6) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 378.32 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Gemcitabine Impurity 16 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H16F2O6 |
| Molecular Weight | 378.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
Related Gemcitabine Standards
- Gemcitabine Impurity 11 (CAS 143157-25-9)
- Gemcitabine Impurity 9 (CAS 143157-22-6)
- Gemcitabine Impurity 10 (CAS 1217452-91-9)
- Gemcitabine Impurity 17 (CAS 197452-15-6)
- Gemcitabine Impurity 29 (CAS 122111-02-8)
- Gemcitabine Impurity 32 (CAS 122111-01-7)
- Gemcitabine monophosphate (disodium) (CAS 1638288-31-9)
- Gemcitabine Impurity 31 (CAS 142816-70-4)
Recommended Standards
- methyl 2-{[di(pentyloxy)phosphoryl]oxy}-3,3,3-trifluoropropanoate (CAS 108682-54-8)
- threo-Mefloquine HCl (CAS 51744-85-5)
- (2R,3R)-4,4-Difluoro-2,5-dihydroxypentane-1,3-diyl dibenzoate (CAS 153012-08-9)
- Perfluorophenyl 2-(4-methyl-6,7-dihydro-4H-thieno[3,2-c]pyran-4-yl)acetate (CAS 916766-89-7)
- Vortioxetine Impurity 37 (CAS 1293489-77-6 (free base))
- Argatroban Impurity 39 (Mixture of Diastereomers) (CAS 184043-01-4)
- Fosfomycin Impurity 76 (CAS CATO-C4X-131676)
- Copper hexadecachlorophthalocyanine (CAS 14832-14-5)
- 2-((tert-Butyldimethylsilyloxy)methyl)-6-((trimethylsilyl)ethynyl)furo[3,2-b]pyridine (CAS 1171920-57-2)
- N-{3-tert-butyl-1-methyl-4-oxo-1H,4H-indeno[1,2-c]pyrazol-6-yl}thiophene-2-carboxamide (CAS 1024523-10-1)
- 1-Benzyl-4-(benzylsulfanyl)phthalazine (CAS 338404-39-0)
- 2,3,4-trimethylpyrrolidine (CAS 51308-51-1)
- 2-(Pyridin-3-yl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine (CAS 1373223-68-7)
- Peptide 442 (CAS CATO-CPTD788442)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com