Crisaborole Impurity 44 CAS 14348-38-0
| CAS No. | 14348-38-0 |
| Molecular Formula | C7H5BrO3 |
| Molecular Weight | 217.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Crisaborole Impurity 44 (CAS 14348-38-0), a pharmacopoeial impurity reference standard (molecular formula C7H5BrO3, MW 217.02 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Crisaborole Impurity 44 (C7H5BrO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 217.02 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5BrO3 |
| Molecular Weight | 217.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole Impurity 6 (CAS 28547-28-6)
- Crisaborole Impurity 43 (CAS 58380-11-3)
- Crisaborole Impurity 36 (CAS 90178-72-6)
- Crisaborole Impurity 44 (CAS 90178-73-7)
- Crisaborole Impurity 6 (CAS 888967-63-3)
- Crisaborole Impurity 18 (CAS 2737-20-4)
- Crisaborole Impurity 41 (CAS 2737-19-1)
- Crisaborole Impurity 42 (CAS 1260761-47-4)
Recommended Standards
- 3-Bromo-2-Hydroxybenzoic Acid (CAS 3883-95-2)
- 5-Bromosalicylic Acid (CAS 89-55-4)
- (8-Methoxy-2-methylquinolin-5-yl)boronic acid (CAS 1107064-35-6)
- 20660-72-4 4-(bromomethyl)-3-nitroPyridine (CAS 20660-72-4)
- Lasmiditan Impurity 15 HCl (CAS CATO-C4X-247815)
- Linezolid Impurity 12 (CAS 1215006-11-3)
- Gefitinib impurity 65 (CAS CATO-C4X-111765)
- tert-butyl (2S)-2-methyl-5-oxopyrrolidine-2-carboxylate (CAS 882392-64-5)
- (1S,4R)-2-Azabicyclo[2.2.1]heptane (CAS 175275-72-6)
- 3-Amino-N-hydroxy-2-pyridinecarboxamide (CAS 98140-94-4)
- 2,4,8,10-Tetraoxaspiro[5.5]undecane (CAS 126-54-5)
- Cyproheptadine impurity 7 (CAS 4331-45-7)
- (1S,3S)-Cyclohexane-1,3-diamine (CAS 860351-60-6)
- (Asp28)-Exenatide trifluoroacetate salt (CAS 1678417-24-7)
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