Crisaborole Impurity 6 CAS 888967-63-3
| CAS No. | 888967-63-3 |
| Molecular Formula | C14H11NO2 |
| Molecular Weight | 225.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Crisaborole Impurity 6 (CAS 888967-63-3) is a certified pharmaceutical impurity reference standard with the molecular formula C14H11NO2 and a molecular weight of 225.24 g/mol.
Based on its molecular formula C14H11NO2, Crisaborole Impurity 6 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 225.24 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Crisaborole Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11NO2 |
| Molecular Weight | 225.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 44 (CAS 90178-73-7)
- Crisaborole Impurity 36 (CAS 90178-72-6)
- Crisaborole Impurity 6 (CAS 28547-28-6)
- Crisaborole Impurity 43 (CAS 58380-11-3)
- Crisaborole Impurity 44 (CAS 14348-38-0)
- Crisaborole Impurity 8 (CAS CATO-C4X-20218)
- Crisaborole impurity 161 (CAS CATO-C4X-2021161)
- Crisaborole Impurity 7 (CAS 2803552-55-6)
Recommended Standards
- Pranoprofen Impurity 37 (CAS CATO-C4X-181137)
- Carteolol Impurity 31 (CAS CATO-C4X-228731)
- Pranoprofen Impurity 1 (CAS 53944-31-3)
- Carbidopa EP Impurity B (CAS 18181-08-3)
- Tafamidis impurity 10 (CAS CATO-C4X-287710)
- Ketoprofen EP Impurity H (CAS 5689-33-8)
- Sitafloxacin Impurity 38 (CAS CATO-C4X-115538)
- 4-(pyridin-2-yloxy)phenol (CAS 68464-71-1)
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- (S)-6-hydroxy-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (CAS 2238820-17-0)
- 1,1-Diphenyl-2-((3-(trifluoromethyl)benzyl)amino)ethan-1-ol hydrochloride (CAS 1052544-46-3)
- 6-Ethyl-7-hydroxy-4-phenyl-2h-chromen-2-one (CAS 130182-00-2)
- Val-Cit-PAB-MMAE (CAS 644981-35-1)
- Macrophage Inhibitory Peptide (CAS 41961-56-2)
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