Crisaborole Impurity 41 CAS 2737-19-1
| CAS No. | 2737-19-1 |
| Molecular Formula | C7H7BrO2 |
| Molecular Weight | 203.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 203.03 g/mol gives Crisaborole Impurity 41 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Crisaborole Impurity 41 (CAS 2737-19-1) is a certified pharmaceutical impurity reference standard with the molecular formula C7H7BrO2 and a molecular weight of 203.03 g/mol.
The molecular framework of Crisaborole Impurity 41 (C7H7BrO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Crisaborole Impurity 41 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H7BrO2 |
| Molecular Weight | 203.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole Impurity 18 (CAS 2737-20-4)
- Crisaborole Impurity 42 (CAS 1260761-47-4)
- Crisaborole Impurity 1 (CAS 20035-32-9)
- Crisaborole Impurity 2 (CAS 196081-71-7)
- Crisaborole Impurity 45 (CAS 2973-80-0)
- Crisaborole Impurity 48 (CAS 22532-61-2)
- Crisaborole Impurity 6 (CAS 28547-28-6)
- Crisaborole Impurity 43 (CAS 58380-11-3)
Recommended Standards
- Palbociclib Impurity 172 (CAS CATO-C4X-1125172)
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- Maribavir Impurity 36 (CAS CATO-C4X-300736)
- Latanoprost EP Impurity C (CAS CATO-C4X-194117)
- Trelagliptin Impurity 63 HCl (CAS CATO-C4X-104663)
- Cabazitaxel Impurity 3 (CAS 1444818-14-7)
- 1-((Diethylamino)methyl)cyclopentan-1-amine dihydrochloride (CAS 2098054-00-1)
- Methyl 4-(1H-1,2,3-triazol-5-yl)benzoate (CAS 796034-28-1)
- 1,2-Oxazole-4-sulfonyl chloride (CAS 933740-94-4)
- 3-(tert-Butoxy)-5-cyclopropoxy-N-methylpyridin-4-amine (CAS 1243375-32-7)
- 4-(p-Dihexadecylaminostyryl)-N-methylquinolinium iodide (CAS 135367-81-6)
- 4-Methoxy-1H-indole-6-carbonitrile (CAS 1427376-90-6)
- Acetyl tetrapeptide-3 (CAS 827306-88-7)
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