Roflumilast Impurity 40 CAS CATO-C4X-108440
| CAS No. | CATO-C4X-108440 |
| Molecular Formula | C17H13ClF2N2O3 |
| Molecular Weight | 366.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Roflumilast Impurity 40 (CAS CATO-C4X-108440, C17H13ClF2N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C17H13ClF2N2O3, Roflumilast Impurity 40 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 366.75 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C17H13ClF2N2O3 |
| Molecular Weight | 366.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Roflumilast Standards
- Roflumilast Impurity 14 (CAS 2206607-17-0)
- Roflumilast Impurity 7 (CAS 1391053-75-0)
- Roflumilast Impurity 57 (CAS CATO-C4X-108457)
- Roflumilast Impurity 36 (CAS CATO-C4X-108436)
- Roflumilast USP Related Compound A (CAS 475271-62-6)
- Roflumilast USP Related Compound B (CAS 1391052-76-8)
- Roflumilast Impurity 32 (CAS 1454574-39-0)
- Roflumilast Impurity 60 (CAS CATO-C4X-193560)
Recommended Standards
- Tert-butyl (S)-3-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)pyrrolidine-1-carboxylate (CAS 1417789-41-3)
- 7-(4-Chlorophenyl)-2-(2,6-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (CAS 860610-86-2)
- (5-Chloro-1-methyl-3-phenyl-1H-pyrazol-4-yl)(2-(trifluoromethyl)phenyl)methanol (CAS 956368-89-1)
- 4-[4-Chloro-6-[2-(difluoromethyl)-1-benzimidazolyl]-1,3,5-triazin-2-yl]morpholine (CAS 475111-38-7)
- Abrocitinib Impurity 45 (CAS CATO-C4X-288445)
- Mosapride Impurity 33 (CAS 116143-27-2)
- Imatinib meta-MPM Impurity (CAS 1246819-59-9)
- 4-Benzyl-6-methylmorpholine-2-carboxylic acid (CAS 1416373-68-6)
- (3Z)-N-(4-Bromophenyl)-3-{[(3,4-dichlorophenyl)methoxy]imino}propanamide (CAS 320417-74-1)
- 2-(2-Fluorophenoxy)-N-(2-(1-methyl-1H-pyrrol-2-yl)-2-morpholinoethyl)acetamide (CAS 1049464-22-3)
- 2-(3,9-Diazaspiro[5.5]Undecan-3-yl)ethan-1-ol (CAS 1552770-41-8)
- 1-[(Tert-butoxy)carbonyl]-1-azaspiro[3.3]heptane-6-carboxylic acid (CAS 1374659-11-6)
- Rocuronium Impurity 51 (CAS 103088-58-0)
- Cholecystokinin Octapeptide (1-4) (desulfated) (CAS 80790-40-5)
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