(2-Bromo-3-chloro-6-fluorophenyl)boronic acid CAS 1451392-82-7
| CAS No. | 1451392-82-7 |
| Molecular Formula | C6H4BBrClFO2 |
| Molecular Weight | 253.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (2-Bromo-3-chloro-6-fluorophenyl)boronic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(2-Bromo-3-chloro-6-fluorophenyl)boronic acid (CAS 1451392-82-7) is a high-purity analytical reference standard with the molecular formula C6H4BBrClFO2 and a molecular weight of 253.26 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, (2-Bromo-3-chloro-6-fluorophenyl)boronic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 253.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4BBrClFO2 |
| Molecular Weight | 253.26 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl/Br-containing |
Related Bromo Standards
- (6-Bromo-3-chloro-2-fluorophenyl)boronic acid (CAS 1451392-87-2)
- (3-Bromo-6-chloro-2-fluorophenyl)boronic acid (CAS 1451393-00-2)
- (3-Bromo-2-chloro-6-fluorophenyl)boronic acid (CAS 1451393-16-0)
- (5-Bromo-3-chloro-2-fluorophenyl)boronic acid (CAS 1451393-27-3)
- (3-Bromo-2-chloro-5-fluorophenyl)boronic acid (CAS 2379538-57-3)
- 3-Bromo-4-chloro-2-fluorophenylboronic acid (CAS 1987879-74-2)
- 3-Bromo-5-chloro-2-fluorophenylboronic acid (CAS 2377608-61-0)
- 3-Bromo-5-chloro-4-fluorophenylboronic acid (CAS 2377608-50-7)
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