3-Bromo-5-chloro-2-fluorophenylboronic acid CAS 2377608-61-0
| CAS No. | 2377608-61-0 |
| Molecular Formula | C6H4BBrClFO2 |
| Molecular Weight | 253.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Bromo-5-chloro-2-fluorophenylboronic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 3-Bromo-5-chloro-2-fluorophenylboronic acid (CAS 2377608-61-0), a certified reference material (molecular formula C6H4BBrClFO2, MW 253.26 g/mol) for analytical method development and quality control.
The molecular framework of 3-Bromo-5-chloro-2-fluorophenylboronic acid (C6H4BBrClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4BBrClFO2 |
| Molecular Weight | 253.26 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl/Br-containing |
Related Bromo Standards
- (2-Bromo-3-chloro-6-fluorophenyl)boronic acid (CAS 1451392-82-7)
- (6-Bromo-3-chloro-2-fluorophenyl)boronic acid (CAS 1451392-87-2)
- (3-Bromo-6-chloro-2-fluorophenyl)boronic acid (CAS 1451393-00-2)
- (3-Bromo-2-chloro-6-fluorophenyl)boronic acid (CAS 1451393-16-0)
- (5-Bromo-3-chloro-2-fluorophenyl)boronic acid (CAS 1451393-27-3)
- (3-Bromo-2-chloro-5-fluorophenyl)boronic acid (CAS 2379538-57-3)
- 3-Bromo-4-chloro-2-fluorophenylboronic acid (CAS 1987879-74-2)
- 3-Bromo-5-chloro-4-fluorophenylboronic acid (CAS 2377608-50-7)
Recommended Standards
- 3-[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]-1,2-dihydropyridin-2-one (CAS 950276-35-4)
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- 3-((1H-Benzo[d][1,2,3]triazol-1-yl)methyl)benzoic acid (CAS 951908-54-6)
- 3-Methyl-1-(3-nitrophenyl)-1H-indazole (CAS 7746-35-2)
- 1,4,4-Trimethylcyclohexane-1-carboxylic acid (CAS 1468421-46-6)
- 4-Chloro-3,5-difluoro-2-methylaniline (CAS 2763538-44-7)
- 6,8-Difluoro-4-methyl-7-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one (CAS 215868-26-1)
- 1-(4-Chloro-3-fluorophenyl)propan-1-ol (CAS 1342500-52-0)
- (2,3-Dihydropyrazolo[5,1-b]thiazol-6-yl)methanol (CAS 623565-45-7)
- 1-(2-((Cyclopropyl(2-hydroxyethyl)amino)methyl)pyrrolidin-1-yl)ethanone (CAS 1353957-93-3)
- 5-((2-Isopropyl-5-methylphenoxy)methyl)furan-2-carboxylic acid (CAS 364746-27-0)
- Manganese Tetrakis(2,6-dichlorophenyl)porphyrin Chloride (CAS 91463-17-1)
- N-(4-fluorophenyl)-2-(isopropylamino)acetamide hydrochloride (CAS 1049768-69-5)
- Semaglutide impurity 103 (CAS 1446013-07-5)
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