(6-Bromo-3-chloro-2-fluorophenyl)boronic acid CAS 1451392-87-2
| CAS No. | 1451392-87-2 |
| Molecular Formula | C6H4BBrClFO2 |
| Molecular Weight | 253.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (6-Bromo-3-chloro-2-fluorophenyl)boronic acid.
(6-Bromo-3-chloro-2-fluorophenyl)boronic acid (CAS 1451392-87-2) is a high-purity analytical reference standard with the molecular formula C6H4BBrClFO2 and a molecular weight of 253.26 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, (6-Bromo-3-chloro-2-fluorophenyl)boronic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 253.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (6-Bromo-3-chloro-2-fluorophenyl)boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4BBrClFO2 |
| Molecular Weight | 253.26 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl/Br-containing |
Related Bromo Standards
- (2-Bromo-3-chloro-6-fluorophenyl)boronic acid (CAS 1451392-82-7)
- (3-Bromo-6-chloro-2-fluorophenyl)boronic acid (CAS 1451393-00-2)
- (3-Bromo-2-chloro-6-fluorophenyl)boronic acid (CAS 1451393-16-0)
- (5-Bromo-3-chloro-2-fluorophenyl)boronic acid (CAS 1451393-27-3)
- (3-Bromo-2-chloro-5-fluorophenyl)boronic acid (CAS 2379538-57-3)
- 3-Bromo-4-chloro-2-fluorophenylboronic acid (CAS 1987879-74-2)
- 3-Bromo-5-chloro-2-fluorophenylboronic acid (CAS 2377608-61-0)
- 3-Bromo-5-chloro-4-fluorophenylboronic acid (CAS 2377608-50-7)
Recommended Standards
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- (7-Hydroxy-2-methylpyrazolo[1,5-a]pyrimidin-6-yl)(phenyl)methanone (CAS 1355182-75-0)
- 2-(3-Amino-1H-indazol-4-yl)benzoic acid (CAS 1464091-59-5)
- (3-Chlorophenyl)(2-iodophenyl)methanone (CAS 890098-14-3)
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- 2-(((2-Hydroxynaphthalen-1-yl)methylene)amino)benzoic acid (CAS 796-47-4)
- 1-(pentan-3-yl)piperidin-4-one (CAS 72544-10-6)
- 5-Chloro-3-cyclopropoxy-2-nitropyridine (CAS 1243450-11-4)
- 5-(2-Chlorophenyl)-N-(3-nitrophenyl)furan-2-carboxamide (CAS 199458-86-1)
- Olaparib Impurity 64 (CAS 155295-47-9)
- 2-(1-((4-Methoxyphenyl)sulfonyl)pyrrolidin-2-yl)benzo[d]thiazole (CAS 551930-96-2)
- Semaglutide impurity 38 (CAS CATO-C4X-222638)
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