Diphenhydramine Hydrochloride CAS 147-24-0
| CAS No. | 147-24-0 |
| Molecular Formula | C17H21NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Diphenhydramine Hydrochloride (C17H21NOHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 291.82 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Diphenhydramine Hydrochloride (CAS 147-24-0), molecular formula C17H21NOHCl and molecular weight 291.82 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H21NO HCl |
| Molecular Weight | 291.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diphenhydramine Standards
- Diphenhydramine EP Impurity C (CAS 118-23-0)
- Diphenhydramine-d6 Hydrochloride (CAS 1189986-72-8)
- Diphenhydramine d5 Hydrochloride (CAS 1219795-16-0)
- Diphenhydramine N-Oxide(hydrochloride) (CAS 13168-00-8)
- Diphenhydramine N-Glucuronide (CAS 137908-78-2)
- Diphenhydramine impurity 18 (CAS 150556-79-9)
- Diphenhydramine EP Impurity A(Dimenhydrinate EP Impurity F) (CAS 17471-10-2)
- Diphenhydramine EP Impurity C HCl (CAS 1808-12-4)
Recommended Standards
- 2-(Methylthio)-4-(trifluoromethyl)phenol (CAS 85092-99-5)
- 3-Bromo-5-methoxypyridine-4-boronic acid (CAS 612845-45-1)
- benzyl (2S)-2-amino-3-(1H-imidazol-4-yl)propanoate;bis(4-methylbenzenesulfonic acid) (CAS 24593-59-7)
- 2-Methoxy-5-(pentafluoro-lambda6-sulfanyl)benzamide (CAS 1706430-65-0)
- {imidazo[1,2-a]pyridin-3-ylmethyl}dimethylamine hydrochloride (CAS 1461708-65-5)
- 3-Amino-5-chloro-4-hydroxybenzenesulfonic acid (CAS 5857-94-3)
- 2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindoline-4-carbonitrile (CAS 444289-04-7)
- 2-(1-Pyrrolidinyl)benzylamine (CAS 72752-53-5)
- 2,2-Dichloro-N,N-diethylacetamide (CAS 921-88-0)
- Acetyl Hexapeptide-38 (CAS 1400634-44-7)
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