Nintedanib Impurity 70 CAS 147149-56-2
| CAS No. | 147149-56-2 |
| Molecular Formula | C9H7Cl2NO3 |
| Molecular Weight | 248.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Nintedanib Impurity 70 (CAS 147149-56-2) is a certified pharmaceutical impurity reference standard with the molecular formula C9H7Cl2NO3 and a molecular weight of 248.06 g/mol.
Based on its molecular formula C9H7Cl2NO3, Nintedanib Impurity 70 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 248.06 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C9H7Cl2NO3 |
| Molecular Weight | 248.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 11 (CAS CATO-C4X-181411)
- Nintedanib Impurity 25 (CAS 262368-25-2)
- Nintedanib Impurity 71 (CAS 2243384-71-4)
- Nintedanib Impurity 31 (CAS 2514952-69-1)
- Nintedanib Impurity 135 (CAS CATO-C4X-1814135)
- Nintedanib Impurity 137 (CAS CATO-C4X-1814137)
- Nintedanib Impurity 138 (CAS CATO-C4X-1814138)
- Nintedanib Impurity 139 (CAS CATO-C4X-1814139)
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