Nintedanib Impurity 37 CAS 14719-83-6

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.14719-83-6
Molecular FormulaC8H6ClNO4
Molecular Weight215.59 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Nintedanib Impurity 37 CAS 14719-83-6 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 215.59 g/mol gives Nintedanib Impurity 37 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Nintedanib Impurity 37 (CAS 14719-83-6), a pharmacopoeial impurity reference standard (molecular formula C8H6ClNO4, MW 215.59 g/mol) used for the identification and quantification of trace impurities in APIs.

Structurally, Nintedanib Impurity 37 (C8H6ClNO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 215.59 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

CATO manufactures Nintedanib Impurity 37 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC8H6ClNO4
Molecular Weight215.59 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor)
Purity>95%
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, ethanol, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1961
Halogen ContentCl-containing
Nitrogen Atoms1

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