Nintedanib Impurity N12 CAS 22911-21-3
| CAS No. | 22911-21-3 |
| Molecular Formula | C10H13ClO3 |
| Molecular Weight | 216.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nintedanib Impurity N12 (CAS 22911-21-3) is a certified pharmaceutical impurity reference standard with the molecular formula C10H13ClO3 and a molecular weight of 216.66 g/mol.
The molecular framework of Nintedanib Impurity N12 (C10H13ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Nintedanib Impurity N12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H13ClO3 |
| Molecular Weight | 216.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity N11 (CAS 91362-61-7)
- Nintedanib Impurity 136 (CAS 70138-33-9)
- Nintedanib Impurity 37 (CAS 14719-83-6)
- Nintedanib Impurity 170 (CAS CATO-C4X-1814170)
- Nintedanib Impurity 30 (CAS 60743-21-7)
- Nintedanib Impurity 31 (CAS 4316-33-0)
- Nintedanib Impurity 91 (CAS CATO-C4X-181491)
- Nintedanib Impurity 111 (CAS CATO-C4X-1814111)
Recommended Standards
- tert-Butyl 4-(chloromethyl)imidazole-1-carboxylate (CAS 500782-71-8)
- N-(5-(tert-butyl)isoxazol-3(2H)-ylidene)-2-chloroacetamide (CAS 55809-27-3)
- 39637-74-6 Camphanoyl chloride 2-Oxabicyclo(2.2.1)heptane-1-carbonyl chloride, 4,7,7-trimethyl-3-oxo-, (1S)- 3-Oxa-2-oxobornane-4-carbonyl chloride Camphanoylchloride EINECS 254-552-4 (CAS 39637-74-6)
- Biphenyl-3-carbonyl chloride (CAS 42498-44-2)
- Revefenacin impurity 80 (CAS CATO-C4X-203180)
- Lifitegrast Impurity 66 (CAS CATO-C4X-240966)
- Sitagliptin Impurity 174 HCl (CAS 486459-88-5（free base）)
- 2-Chloro-3-cyclopropoxy-4-isopropoxypyridine (CAS 1243353-24-3)
- (3-(Aminomethyl)piperidin-1-yl)(3-fluoropyridin-4-yl)methanone (CAS 1479261-12-5)
- 5-Methyl-2-phenyl-1H-imidazo[4,5-b]pyridine (CAS 88406-57-9)
- Dimethyl 3-hydroxyphthalate (CAS 36669-02-0)
- 4-Chloro-4'-nitrobenzophenone, 97% (CAS 7497-60-1)
- S-Methyl 4-amino-2-ethoxypyrimidine-5-carbothioate (CAS 383160-10-9)
- Des-Gln19-Tirzepatide (CAS CATO-CPTD788954)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com