Nintedanib Impurity 136 CAS 70138-33-9
| CAS No. | 70138-33-9 |
| Molecular Formula | C10H13ClO3 |
| Molecular Weight | 216.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Nintedanib Impurity 136 (C10H13ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 216.66 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Nintedanib Impurity 136 (CAS 70138-33-9, C10H13ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nintedanib Impurity 136 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H13ClO3 |
| Molecular Weight | 216.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity N11 (CAS 91362-61-7)
- Nintedanib Impurity N12 (CAS 22911-21-3)
- Nintedanib Impurity 37 (CAS 14719-83-6)
- Nintedanib Impurity 170 (CAS CATO-C4X-1814170)
- Nintedanib Impurity 30 (CAS 60743-21-7)
- Nintedanib Impurity 31 (CAS 4316-33-0)
- Nintedanib Impurity 91 (CAS CATO-C4X-181491)
- Nintedanib Impurity 111 (CAS CATO-C4X-1814111)
Recommended Standards
- Cetirizine Impurity 10 (CAS 1016-78-0)
- Terbacil (CAS 5902-51-2)
- Clotrimazole EP Impurity E (CAS 5162-03-8)
- n-(2-Aminoethyl)-4-chloro-1,5-dimethyl-1h-pyrazole-3-carboxamide (CAS 1001519-21-6)
- Fudosteine Impurity 70 (CAS 3958-14-3)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
- Procaterol Impurity 29 (CAS CATO-C4X-181029)
- (S)-3-((tert-butoxycarbonyl)amino)-2-(3-fluorobenzyl)propanoic acid (CAS 1260607-53-1)
- 5-(Tert-butyl)thiophene-2-carbonitrile (CAS 685120-66-5)
- methyl bicyclo[2.1.1]hexane-1-carboxylate (CAS 141046-53-9)
- Amorolfine Hydrochloride - Impurity G (CAS 1260498-34-7)
- 5-Methoxy-6-nitropicolinaldehyde (CAS 397309-59-0)
- 4-(Chloromethyl)-3-methyl-1-phenyl-1h-pyrazole (CAS 99853-52-8)
- Vialox Peptide(Pentapeptide-3) diacetate (CAS 725232-44-0)
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