Nintedanib Impurity N11 CAS 91362-61-7
| CAS No. | 91362-61-7 |
| Molecular Formula | C10H13ClO3 |
| Molecular Weight | 216.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Nintedanib Impurity N11 (CAS 91362-61-7) is a certified pharmaceutical impurity reference standard with the molecular formula C10H13ClO3 and a molecular weight of 216.66 g/mol.
Structurally, Nintedanib Impurity N11 (C10H13ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 216.66 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13ClO3 |
| Molecular Weight | 216.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity N12 (CAS 22911-21-3)
- Nintedanib Impurity 136 (CAS 70138-33-9)
- Nintedanib Impurity 37 (CAS 14719-83-6)
- Nintedanib Impurity 170 (CAS CATO-C4X-1814170)
- Nintedanib Impurity 30 (CAS 60743-21-7)
- Nintedanib Impurity 31 (CAS 4316-33-0)
- Nintedanib Impurity 91 (CAS CATO-C4X-181491)
- Nintedanib Impurity 111 (CAS CATO-C4X-1814111)
Recommended Standards
- N-(5-(tert-butyl)isoxazol-3(2H)-ylidene)-2-chloroacetamide (CAS 55809-27-3)
- Biphenyl-3-carbonyl chloride (CAS 42498-44-2)
- tert-Butyl 4-(chloromethyl)imidazole-1-carboxylate (CAS 500782-71-8)
- Acotiamide related compound 4 (CAS 53811-44-2)
- Nebivolol Impurity 16 (CAS 99199-91-4)
- Clomifene Impurity 8 (CAS 23464-17-7)
- Cefpodoxime Proxetil Impurity 18 (CAS CATO-C4X-157918)
- 8a-methyl-hexahydro-1H-pyrrolo[2,1-c]morpholine-3-carbonitrile (CAS 1803566-52-0)
- 1-(4-(4-Hydroxybutyl)phenyl)ethan-1-one (CAS 100256-34-6)
- 5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine (CAS 870689-06-8)
- 4-(Hydroxyamino)thiazol-2(5H)-one (CAS 19387-59-8)
- 4-methylquinolin-8-ol hydrobromide (CAS 1803608-18-5)
- 4-((4-Chloro-3-fluorobenzyl)oxy)benzaldehyde (CAS 1443305-52-9)
- Hexapeptide-11 (CAS 161258-30-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com