Dasatinib Impurity 46 CAS CATO-C4X-160746
| CAS No. | CATO-C4X-160746 |
| Molecular Formula | C16H14ClN5OS |
| Molecular Weight | 359.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Dasatinib Impurity 46 (CAS CATO-C4X-160746, C16H14ClN5OS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H14ClN5OS, Dasatinib Impurity 46 contains a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 359.83 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H14ClN5OS |
| Molecular Weight | 359.83 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Dasatinib Standards
- Dasatinib Impurity 74 (CAS CATO-C4X-160774)
- Dasatinib Impurity N57 (CAS 1245157-42-9)
- Dasatinib impurity 67 (CAS 302964-06-3)
- Dasatinib Impurity 55 (CAS CATO-C4X-160755)
- Dasatinib impurity 60 (CAS CATO-C4X-160760)
- Dasatinib Impurity 73 (CAS CATO-C4X-160773)
- Dasatinib Impurity 29 (CAS CATO-C4X-160729)
- Dasatinib Dichloro Impurity (CAS 302964-08-5)
Recommended Standards
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