Medroxyprogesterone impurity 10 CAS 15399-87-8
| CAS No. | 15399-87-8 |
| Molecular Formula | C22H30O3 |
| Molecular Weight | 342.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 342.47 g/mol gives Medroxyprogesterone impurity 10 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Medroxyprogesterone impurity 10 (CAS 15399-87-8) is a certified pharmaceutical impurity reference standard with the molecular formula C22H30O3 and a molecular weight of 342.47 g/mol.
Medroxyprogesterone impurity 10 (C22H30O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H30O3 |
| Molecular Weight | 342.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
Related Medroxyprogesterone Standards
- Medroxyprogesterone Impurity N3 (CAS 13254-82-5)
- Medroxyprogesterone Acetate EP Impurity I (CAS CATO-C4X-14573)
- Medroxyprogesterone (CAS 520-85-4)
- Medroxyprogesterone impurity 9 (CAS 14510-23-7)
- Medroxyprogesterone Acetate Impurity 6 (CAS 1097-51-4)
- Medroxyprogesterone Impurity N2 (CAS 77881-13-1)
- Medroxyprogesterone Acetate EP Impurity H (CAS 302-23-8)
- Medroxyprogesterone Impurity 13 (CAS CATO-C4X-145713)
Recommended Standards
- Megestrol Acetate EP Impurity B (CAS 3562-63-8)
- Progesterone Impurity 50 (CAS 64662-12-0)
- Spironolactone EP Impurity C (CAS 976-70-5)
- Progesterone Impurity 80 (CAS CATO-C4X-150280)
- Apixaban Impurity 77 (CAS 438056-68-9)
- Cabozantinib Impurity 52 (CAS CATO-C4X-201852)
- Trametinib impurity 26 (CAS CATO-C4X-27826)
- 1'-Benzyl-3H-spiro[benzofuran-2,4'-piperidine] (CAS 71916-71-7)
- 2-Chloro-4,6-dimethylnicotinonitrile (CAS 14237-71-9)
- 2-(4-(Trifluoromethyl)phenyl)-1H-benzo[d]imidazole (CAS 400073-79-2)
- 1-Methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-benzo[d]imidazol-2-amine (CAS 330793-28-7)
- Isocarboxazid (CAS 59-63-2)
- 2-Bromo-6-fluoro-3-(trifluoromethyl)benzamide (CAS 2091605-54-6)
- D-[Ser]8-Semaglutide (CAS CATO-C4X-2226207)
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