Cabozantinib Impurity 52 CAS CATO-C4X-201852
| CAS No. | CATO-C4X-201852 |
| Molecular Formula | C14H12F2N2 |
| Molecular Weight | 246.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cabozantinib Impurity 52.
CATO supplies Cabozantinib Impurity 52 (CAS CATO-C4X-201852), a pharmacopoeial impurity reference standard (molecular formula C14H12F2N2, MW 246.26 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Cabozantinib Impurity 52 (C14H12F2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cabozantinib Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H12F2N2 |
| Molecular Weight | 246.26 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Cabozantinib Standards
- Cabozantinib Impurity 40 (CAS 1275738-77-6)
- Cabozantinib Impurity N2 (CAS 113136-79-1)
- Cabozantinib Impurity 4 (CAS CATO-C4X-20184)
- Cabozantinib 4-Fluorocarbamoyl Methyl Ester Impurity (CAS 1345847-71-3)
- Cabozantinib Impurity 21 (CAS 849217-49-8)
- Cabozantinib Impurity 19 (CAS CATO-C4X-201819)
- Cabozantinib Impurity 43 (CAS CATO-C4X-201843)
- Cabozantinib Impurity 28 (CAS 326-04-5)
Recommended Standards
- Ozagrel Impurity 1 (CAS CATO-C4X-19711)
- Florfenicol Impurity 10 (CAS 3029320-86-0)
- Lenalidomide Impurity 30 (CAS 13726-85-7)
- Florfenicol Impurity 9 (CAS 2991239-50-8)
- Glycine EP Impurity C (CAS 79-11-8)
- Dapoxetine Impurity 103 (CAS 1135682-44-8)
- Carbazochrome Impurity 12 (CAS CATO-C4X-229112)
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- 6-Chloro-N-(tetrahydro-2H-pyran-4-ylmethyl)-2-pyridinamine (CAS 1219967-41-5)
- 1-(4,6-Dichloropyridin-3-yl)-2,2-difluoroethan-1-one (CAS 2229238-42-8)
- Zinc Acetate dihydrate (CAS 5970-45-6)
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Why CATO?
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