Trazodone Impurity 58 CAS 157072-20-3
| CAS No. | 157072-20-3 |
| Molecular Formula | C19H22ClN5O |
| Molecular Weight | 371.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trazodone Impurity 58.
Trazodone Impurity 58 (CAS 157072-20-3) is a certified pharmaceutical impurity reference standard with the molecular formula C19H22ClN5O and a molecular weight of 371.86 g/mol.
Based on its molecular formula C19H22ClN5O, Trazodone Impurity 58 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 371.86 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Trazodone Impurity 58 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H22ClN5O |
| Molecular Weight | 371.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Trazodone Standards
- Trazodone EP Impurity C (CAS 157072-19-0)
- Trazodone Hydrochloride EP Impurity M (CAS 157072-18-9 (cation form))
- Trazodone impurity 47 (CAS CATO-C4X-177247)
- Trazodone (CAS 19794-93-5)
- Trazodone impurity 51 (CAS CATO-C4X-177251)
- Trazodone Impurity 85 (CAS CATO-C4X-177285)
- Trazodone Impurity 110 (CAS CATO-C4X-1772110)
- Trazodone EP Impurity A (CAS 55290-68-1)
Recommended Standards
- Amodiaquine Impurity 3 (CAS 102391-07-1)
- Metoclopramide Impurity 127 (CAS CATO-C4X-1415127)
- 2,5,7-Tribromobenzo[d]thiazole, 97% (CAS 1190321-91-5)
- N-(2-(4-(4-chlorophenyl)piperazin-1-yl)-2-oxoethyl)-3-methylbenzamide (CAS 338419-57-1)
- Morinidazole Impurity 5 (CAS CATO-C4X-21965)
- Cabozantinib Impurity 8 (CAS 213699-53-7)
- N-Nitroso Levodropropizine EP Impurity B (CAS 14340-33-1)
- 4-Butylpyrimidin-2-amine (CAS 30537-99-6)
- Etapenem Impurity 42 (CAS CATO-C4X-163342)
- 2-(2-(Bromomethyl)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2096332-57-7)
- 8-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (CAS 41565-83-7)
- 3-(6-Oxo-3-(pyridin-2-yl)pyridazin-1(6H)-yl)propanoic acid (CAS 1283108-19-9)
- 3-Cyano-5-cyclopropoxybenzamide (CAS 1243452-41-6)
- Acetyl Tripeptide-1 (CAS 350595-76-5)
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