Trazodone EP Impurity C CAS 157072-19-0
| CAS No. | 157072-19-0 |
| Molecular Formula | C19H22ClN5O |
| Molecular Weight | 371.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 371.86 g/mol gives Trazodone EP Impurity C distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Trazodone EP Impurity C (CAS 157072-19-0) is a certified pharmaceutical impurity reference standard with the molecular formula C19H22ClN5O and a molecular weight of 371.86 g/mol.
The molecular framework of Trazodone EP Impurity C (C19H22ClN5O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22ClN5O |
| Molecular Weight | 371.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Trazodone Standards
- Trazodone Hydrochloride EP Impurity M (CAS 157072-18-9 (cation form))
- Trazodone impurity 47 (CAS CATO-C4X-177247)
- Trazodone Impurity 58 (CAS 157072-20-3)
- Trazodone (CAS 19794-93-5)
- Trazodone impurity 51 (CAS CATO-C4X-177251)
- Trazodone Impurity 85 (CAS CATO-C4X-177285)
- Trazodone Impurity 110 (CAS CATO-C4X-1772110)
- Trazodone EP Impurity A (CAS 55290-68-1)
Recommended Standards
- Ethyl 2-(4-(4-chlorophenyl)-2,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl)-2-oxoacetate (CAS 1374509-57-5)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2-chlorophenyl)methanone (CAS 898756-22-4)
- Fmoc-Leu-Cl (CAS 103321-59-1)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3-chlorophenyl)methanone (CAS 898756-00-8)
- Maribavir Impurity 27 (CAS CATO-C4X-300727)
- Favipiravir Impurity 21 (CAS CATO-C4X-210221)
- Vilanterol Impurity 80 (CAS 2514963-34-7)
- 1-Ethynyl-2,4-dimethoxybenzene (CAS 77336-36-8)
- Rivaroxaban Impurity 88 (CAS CATO-C4X-109088)
- Nintedanib Impurity 159 (CAS CATO-C4X-1814159)
- 3-(3-Chlorothiophen-2-yl)-1H-pyrazole (CAS 166196-59-4)
- Ursodeoxycholic Acid Impurity 22 (CAS 566-24-5)
- 2-(5-((4-Methoxyphenoxy)methyl)-1,2,4-oxadiazol-3-yl)-N-methylethanamine hydrochloride (CAS 1306738-86-2)
- Semaglutide Impurity 180 (CAS CATO-C4X-2226180)
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