Olaparib Impurity N12 CAS 763114-04-1
| CAS No. | 763114-04-1 |
| Molecular Formula | C25H27FN4O4 |
| Molecular Weight | 466.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Olaparib Impurity N12.
CATO supplies Olaparib Impurity N12 (CAS 763114-04-1), a pharmacopoeial impurity reference standard (molecular formula C25H27FN4O4, MW 466.50 g/mol) used for the identification and quantification of trace impurities in APIs.
Olaparib Impurity N12 (C25H27FN4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H27FN4O4 |
| Molecular Weight | 466.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Olaparib Standards
- Olaparib Impurity 28 (CAS 1187479-72-6)
- Olaparib Impurity 49 (CAS CATO-C4X-113549)
- Olaparib Impurity 40 (CAS CATO-C4X-113540)
- Olaparib Impurity 128 (CAS CATO-C4X-1135128)
- Olaparib Impurity 161 (CAS CATO-C4X-1135161)
- Olaparib Impurity 83 (CAS CATO-C4X-113583)
- Olaparib Impurity 84 (CAS CATO-C4X-113584)
- Olaparib Impurity 118 (CAS CATO-C4X-1135118)
Recommended Standards
- 1,3,6,8-Tetra(1H-imidazol-1-yl)pyrene (CAS 2247718-42-7)
- Risperidone Impurity 38 (CAS CATO-C4X-111138)
- Acalabrutinib Impurity 22 (CAS CATO-C4X-305522)
- Cefazolin Impurity 71 (CAS CATO-C4X-157771)
- Polidocanol Impurity 7 (CAS CATO-C4X-29447)
- Avibactam impurity 112 (CAS 1416134-58-1&1463522-16-8)
- Bempedoic Acid Impurity 46 (CAS 684206-36-8)
- 5-Chloro-2-methylquinoxaline (CAS 76982-24-6)
- 3-(1-Ethyl-1h-indazol-3-yl)propanal (CAS 1493603-82-9)
- N'-(2-Chlorobenzylidene)-3-isopropyl-1H-pyrazole-5-carbohydrazide (CAS 303106-35-6)
- 3,3-Bis(Hydroxymethyl)cyclobutan-1-one (CAS 305819-01-6)
- (E)-5-(3,3-Dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide (CAS 750512-03-9)
- 6-Chloro-5-methylpyrazolo[1,5-a]pyrimidin-7-ol (CAS 853030-20-3)
- Custom peptides (CAS CATO-CPTD788509)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com